Results 91 to 100 of about 198,726 (292)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
APPROPRIATENESS OF USING 3D GRAPHICS WHEN TRAINING MILITARY SPECIALISTS
Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2014 Problems of financing with Armed Forces of Ukraine cause necessity of application productive and cost-effective methods of military specialists training.
Anatolii Y. Dereviyanchuk +1 more
doaj
Realistic 3D Simulators for Automotive: A Review of Main Applications and Features
SensorsRecent advancements in vehicle technology have stimulated innovation across the automotive sector, from Advanced Driver Assistance Systems (ADAS) to autonomous driving and motorsport applications.
Ivo Silva +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Accelerating Berends–Giele recursion for gluons in arbitrary dimensions over finite fields
European Physical Journal C: Particles and FieldsThis work provides a proof of concept for the computation of pure gluonic amplitudes in quantum chromodynamics (QCD) on graphics processing units (GPUs). The implementation relies on the Berends–Giele recursion algorithm and, for the first time on a GPU,
Juan Cruz-Martinez +2 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Hardware Implementation Of Line Clipping A lgorithm By Using FPGA
Tikrit Journal of Engineering Sciences, 2011 The computer graphics system performance is increasing faster than any other computing application. Algorithms for line clipping against convex polygons and lines have been studied for a long time and many research papers have been published so far.
Amar I. Dawod
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source