Results 111 to 120 of about 3,518,526 (296)

Real-world study: from real-world data to real-world evidence [PDF]

Translational Breast Cancer Research, 2020
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Patient Disease Characteristics and Treatment Patterns in Mild–Moderate Psoriasis: Results from Real-World Clinical Practice in the United States (PROSPECT Study)

Dermatology and Therapy
Introduction Psoriasis (PsO) is a common dermatological condition. Psoriasis severity is commonly characterized by percentage body surface area (BSA) affected, with
Emily J. Goddard, James M. Haughton, James E. Lucas, Sophie G. Barlow, Timothy P. Fitzgerald, Alexander M. Litvintchouk, David Wu   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Demographics and Clinical Characteristics among Patients with Distinct Psychosocial Burden Profiles Related to Vitiligo: Results of a Latent Class Analysis

Dermatology and Therapy
Introduction Vitiligo may negatively impact quality of life (QOL). This study aimed to classify patients on the basis of the impact of vitiligo on emotional/psychological and social functioning and describe patient characteristics and patient-reported ...
Kent A. Hanson, Khaled Ezzedine, Jenny Austin, Peter Anderson, Simran Marwaha, Samantha K. Kurosky, Roni Adiri, James Piercy, Ernest H. Law   +8 more
doaj   +1 more source

Bootstrapping Real-world Deployment of Future Internet Architectures

, 2015
The past decade has seen many proposals for future Internet architectures. Most of these proposals require substantial changes to the current networking infrastructure and end-user devices, resulting in a failure to move from theory to real-world ...
Barrera, David, Lee, Heejo, Lee, Taeho, Perrig, Adrian, Szalachowski, Pawel, Watrin, David   +5 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Outcomes of patients with COPD switching from multiple-inhaler to once-daily single-inhaler triple therapy in a real-world primary care setting in England: a retrospective pre-post cohort study

BMJ Open Respiratory Research
Background Compared with multiple-inhaler triple therapy (MITT), single-inhaler triple therapy (SITT) with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) demonstrated improved lung function and meaningful improvements in chronic obstructive ...
Raj Sharma, Claus F Vogelmeier, Kieran J Rothnie, David M G Halpin, Alexandrosz Czira, Chris Compton, Afisi S Ismaila, Robert P Wood, Victoria L Banks, Lucinda J Camidge, Olivia K I Massey, Monica Seif   +11 more
doaj   +1 more source

Real world evidence [PDF]

British Dental Journal, 2012
openaire   +2 more sources