Results 91 to 100 of about 23,126,500 (355)

Real-world satisfaction and experience with injection and autoinjector device for ofatumumab indicated for multiple sclerosis

BMC Neurology
Background To evaluate the overall satisfaction, device usability, and injection experience of MS patients self-administering ofatumumab using the Sensoready® autoinjector device in the United States (US).
Amy Perrin Ross, Jacqueline Nicholas, Ming-Hui Tai, Stephen Yeung, Nazneen Fatima Shaikh, Helen Chen, Mariana Fernandes, Aaron Cortright, Kevin Hawkins   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Caregiver burden in Duchenne muscular dystrophy in Europe, Japan, and the United States – a real-world study

BMC Neurology
Background The rare genetic disease Duchenne muscular dystrophy (DMD) mostly affects males, impacting mobility and pulmonary/cardiac function from childhood.
Jonathan Strober, Keiko Ishigaki, Nate Posner, Joseph C. Cappelleri, Sherry Xiao, Anna Talaga, Stephen Dukacz, Halima Iqbal, Emma Chatterton, Ella Morton, Sarah Weatherby, Jonathan de Courcy   +11 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Little Data Book 2011

, 2011
The little data book 2011 is a pocket edition of world development indicators 2011. It is intended as a quick reference for users of the world development indicators database, book, and CD-ROM. The database, which
World Bank
core   +1 more source

Real-World Experience with an Adalimumab Biosimilar (ABP 501) in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis and Psoriasis in Europe: Results from the Adelphi Disease Specific Programme

Rheumatology and Therapy
Introduction Biosimilars have provided additional treatment options for patients with immune-mediated inflammatory diseases. This study evaluated the real-world use of adalimumab biosimilar ABP 501 in European patients with rheumatoid arthritis (RA ...
Ran Jin, James M. Haughton, Emily J. Goddard, Delphine Courmier, Waldemar Radziszewski, Rachael H. Meadows, James Piercy, Stanley Cohen   +7 more
doaj   +1 more source

The multifaceted impact of anxiety and depression on patients with rheumatoid arthritis

BMC Rheumatology, 2019
Background The prevalence of mood disturbances such as anxiety and depression is greater in rheumatoid arthritis (RA) patients than in the general population.
Steve Peterson, James Piercy, Stuart Blackburn, Emma Sullivan, Chetan S. Karyekar, Nan Li   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

World Development Indicators 2008 [PDF]

, 2008
Release of the final report of the International Comparison Program (ICP) and publication of new estimates of purchasing power parities (PPPs) in World Development Indicators 2008 are an important statistical milestone.
World Bank
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source