Results 121 to 130 of about 16,717,089 (314)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
ClinicoEconomics and Outcomes ResearchYestle Kim,1 Ni Zeng,2 Jessamine P Winer-Jones,2 Machaon Bonafede,2 Francis Lobo,1 John O’Donnell,1 Taylor Ryan2 1Health Economics and Outcomes Research Madrigal Pharmaceuticals, Inc, West Conshohocken, PA, USA; 2Real World Evidence, Veradigm, Chicago ...
Kim Y +6 more
doaj
Chronic Kidney Disease-Associated Pruritus Burden: A Patient Survey Study
Kidney MedicineRationale & Objective: Chronic kidney disease-associated pruritus (CKD-aP) is a common, underrecognized condition in patients with chronic kidney disease (CKD), especially those receiving hemodialysis (HD).
Jeffrey Thompson +7 more
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Evidence for Heuristic Evidence Weighting in Real-World Beliefs.
, 2023 Cognitive models of learning often propose that belief formation is rational: new experience is combined with prior belief to support statistically optimal inferences. Why then are false beliefs so ubiquitous and difficult to correct? Prior work using a novel category-learning paradigm suggests that false beliefs may arise from the way that learners ...
Frigo, Vincent, Rogers, Timothy T
openaire +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source