Results 141 to 150 of about 1,338,680 (315)

Machine learning to identify chronic cough from administrative claims data

Scientific Reports
Accurate identification of patient populations is an essential component of clinical research, especially for medical conditions such as chronic cough that are inconsistently defined and diagnosed.
Vishal Bali, Vladimir Turzhitsky, Jonathan Schelfhout, Misti Paudel, Erin Hulbert, Jesse Peterson-Brandt, Jeffrey Hertzberg, Neal R. Kelly, Raja H. Patel   +8 more
doaj   +1 more source

Can TB Patients Help Successfully Identify Others for Testing?

, 2019
Tuberculosis is an infectious bacterial disease spread through the air that can lead to death when left untreated. The disease killed some 1.6 million people in 2017, according to the World Health Organization ...
World Bank
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Moving Beyond Viral Suppression: Poor Patient–Provider Communication and Its Impact on Healthcare Outcomes Among People Living With HIV in the United States

Journal of the International Association of Providers of AIDS Care
Background While advancement in treatment have turned HIV into a manageable chronic condition achieving viral suppression, it has become imperative to focus on overall health and improving health-related quality of life of people living with HIV (PLHIV ...
Bekana K. Tadese MPH, PhD, M. Janelle Cambron-Mellott PhD, Jean Marie Arduino ScD, MS, Bridget L. Balkaran MPH, Shakiba Eslamimehr PhD, José M. Zuniga PhD, MPH   +5 more
doaj   +1 more source

Trial Emulation and Real-World Evidence [PDF]

JAMA Network Open, 2021
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Reliability of Real-world data: a review and meta-analysis to evaluate the consistency of Real-world data collection from Compassionate Use programs and corresponding Registration trials

openNegli ultimi anni, le costanti nuove scoperte nell’ambito dei biomarcatori e di formulazione hanno consentito di accelerare notevolmente il processo di sviluppo di farmaci, specialmente in ambito oncologico, comportando una più veloce introduzione ...
PERIN, LEONARDO
core  

A New Era for Real-World Evidence

, 2019
This presentation will use cancer therapeutic development as a use case for exploring the emerging role of real-world evidence. The current availability of electronic health records with rich information about patients gathered during their routine care ...
Meropol, MD, Neal J.
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source