Results 81 to 90 of about 16,717,089 (314)

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Environment Matters at the World Bank : Annual Review 2005 [PDF]

open access: yes, 2005
In line with one of the major themes in the Bank's Environment Strategy, this 2005 annual review is devoted to the theme of environmental health. Viewpoint articles in this edition reflect several external
World Bank
core   +1 more source

Real-world challenges associated with the use of four common systemic glucocorticoids in a United States IgAN cohort

open access: yesFrontiers in Nephrology
ObjectivesTo understand the difference in adverse events (AEs), healthcare resource utilization (HCRU), and kidney failure rates in immunoglobulin A nephropathy (IgAN) patients who initiated systemic glucocorticoid (SGC) treatment compared with those who
Giancarlo Pesce   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

World Real Interest Rates [PDF]

open access: yes
We think of the expected real interest rate for ten OECD countries (our counterpart of the world economy) as determined by the equation of aggregate investment demand to aggregate desired saving.
Robert J. Barro, Xavier Sala-i-Martin
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

US-England (Flatiron/NCRAS) de Novo mBC Transportability Study Protocol and Statistical Analysis Plan

open access: yes
This study will assess the transportability of real-world evidence from the US to England for individuals diagnosed with de novo metastatic breast cancer based on data from NCRAS and Flatiron Health.
Philani Brian Mpofu   +4 more
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Real-World Reinforcement Learning

open access: yes, 2021
This is our first public release of real-world reinforcement learning, a document with associated code showing how to design and deploy reinforcement learning solutions in customer-facing applications.If you use this software, please cite it as ...
Mason, Douglas
core   +1 more source

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