Results 81 to 90 of about 1,338,680 (315)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Real-world evidence [PDF]

Annals of Allergy, Asthma & Immunology, 2021
John Oppenheimer, David J. Slade, Beth A. Hahn, Laurie Zografos, Alicia Gilsenan, David Richardson, David McSorley, Robson Lima, Nestor A. Molfino, Carlyne M. Averell   +9 more
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The Little Data Book on Private Sector Development 2010

, 2010
The global financial crisis has led to rising interest in private sector development and economic growth. There is strong evidence that crises can stimulate investment climate reform.
World Bank
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Real-world challenges associated with the use of four common systemic glucocorticoids in a United States IgAN cohort

Frontiers in Nephrology
ObjectivesTo understand the difference in adverse events (AEs), healthcare resource utilization (HCRU), and kidney failure rates in immunoglobulin A nephropathy (IgAN) patients who initiated systemic glucocorticoid (SGC) treatment compared with those who
Giancarlo Pesce, Mit Patel, Gaelle Gusto, Ananth Kadambi, Aastha Chandak, Terri Madison   +5 more
doaj   +1 more source

World Real Interest Rates [PDF]

We think of the expected real interest rate for ten OECD countries (our counterpart of the world economy) as determined by the equation of aggregate investment demand to aggregate desired saving.
Robert J. Barro, Xavier Sala-i-Martin
core  

The Little Data Book on Private Sector Development 2009

, 2009
The little data book on private sector development coincides with the unfolding of the global financial crisis. There is strong evidence that crises can stimulate reform of the investment climate. A better
World Bank
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Real world data: an opportunity to supplement existing evidence for the use of long-established medicines in health care decision making

, 2018
Vaibhav B Katkade, Kafi N Sanders, Kelly H Zou Pfizer Inc, New York, NY, USA Abstract: Evidence from medication use in the real world setting can help to extrapolate and/or augment data obtained in randomized controlled trials and establishes a broad ...
Sanders KN, Zou KH, Katkade VB
core