Results 71 to 80 of about 294,417 (304)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Impact of NOx vehicle emission standards failure on Air Quality in Europe [PDF]

, 2012
Vehicle exhaust emission standards have been tightened in the EU for several decades now, in order to protect health and the environment. This has led to a substantial decrease in total pollutant emissions, despite the growing volumes of passenger and ...
Borken-Kleefeld, J., Kiesewetter, G., Ntziachristos, L., Papageorgiou, T.   +3 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Emissions pollutant from diesel, biodiesel and natural gas refuse collection vehicles in urban areas [PDF]

, 2010
Urban pollution is more and more concern due to human health implications. In that way, emissions pollutant from commercial vehicles which move daily at fixed itineraries such as, buses and refuse collection vehicles must be monitored.
Aparicio Izquierdo, Francisco, Flores Holgado, María Nuria, Jiménez Alonso, Felipe, López Martínez, José María   +3 more
core   +1 more source

Interference-induced peak splitting in EUV superfluorescence [PDF]

, 2012
We investigate the laser-induced quantum interference in EUV superfluorescence occurring in a dense gas of $\Lambda$-type helium atoms coupled by a coherent laser field in the visible region.
Agostini, Ariunbold, Christoph H. Keitel, Dicke, Dreher, Dutt, Faist, Gibbs, Gisselbrecht, Kiffner, Kiffner, Luo, Mihai Macovei, Nagasono, Ni Cui, Noe, Paradis, Schmidt, Sete, Skribanowitz, Taichenachev, Watanabe   +21 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Real-time simulation of finite frequency noise from a single electron emitter

, 2012
We study the real-time emission of single electrons from a quantum dot coupled to a one dimensional conductor, using exact diagonalization on a discrete tight-binding chain.
Jonckheere, T., Martin, T., Rech, J., Stoll, T.   +3 more
core   +3 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

A methodology to creating semi-artificial city driving cycle: case study of Istanbul

Journal of Engineering and Applied Science, 2022
This study describes the methodology of creating Semi - Artificial City Cycle (SACC), which can be used for emission tests of road vehicles; sustainability of hybrid electric vehicle (HEV); or emission inventories of the city.
Muhammet Aydın, Cem Soruşbay
doaj   +1 more source