Results 81 to 90 of about 7,029,557 (297)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A Mobile Computing Based Tool for Low-Emission Driving

, 2023
Margaritis, Dimitris/0000-0001-5056-1170; Dimokas, Nikos/0000-0003-2856-0969Recent advances in communications and mobile computing boosted the green mobility.
Margaritis, Dimitris, Faye, Sebastien, Camino, Ramiro, Ozatay, Engin, Alankus, Orhan, Dimokas, Nikos   +5 more
core   +1 more source

Influence of the Particulate Filter Use in the Spark Ignition Engine Vehicle on the Exhaust Emission in Real Driving Emission Test [PDF]

, 2020
The introduction of new exhaust emissions norms for motor vehicles forces manufacturers to rely on th new technologies of exhaust gas aftertreatment and emission reduction.
Szymlet, Natalia, Siedlecki, Maciej, Sokolnicka, Barbara   +2 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The rise of real drive emission to mitigate difference of lab tests and on-road emission

, 2020
Air pollution caused by vehicle emissions has drawn serious concern about public health. Vehicle emissions generally depend on many factors viz. nature of the vehicle, driving style, traffic conditions, emission control technologies, and operational ...
Mahlia, TM Indra, Hassan, Mohammad Mahmudul, Tausif Murshed, Murshed, Tausif, Rahman, Akibur, Mohammad Al Mahdi Hasan, Fattah, I. M. Rizwanul, Imran, Md Ashraful, S M Ashrafur Rahman, I. M. Rizwanul Fattah, Ashik, Fajle Rabbi, Fajle Rabbi Ashik, Md Hamidur Rahman, Rahman, S M Ashrafur, Rahman, Hamidur, Hasan, Mohammad Al Mahdi, Md Ashraful Imran, TM Indra Mahlia, Mohammad Mahmudul, Md Akibur Rahman   +19 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Methodology to analyse the dynamic conditions of real driving emission test and CO2 emission factors: speed binning averaged emission method

, 2022
Regulations limiting the exhaust gas emissions since the EURO I emission standards, which was put into effect in 1992, have entered a new period since 2017 and require Real Driving Emission (RDE) tests as well as laboratory tests.
Arslan, Hikmet, Aydin, Muhammet, Sorusbay, Cem   +2 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

RDE & dynamometer analysis of light-duty vehicle emissions across altitudes, temperatures, and driving styles.

PLoS ONE
This study aimed to investigate the impact of altitude, cold start, ambient temperatures, and driving behaviors on the Real Driving Emissions (RDE) of China VI standard light-duty gasoline vehicles.
Jiguang Wang, Li Wang, Jiaqiang Li, Jianwei Li, Feng Xu, Fei Han, Jianliang He, Qiuling Chen, Xudong Chen   +8 more
doaj   +1 more source