Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Real World Fuel Consumption and Emissions From LDVs and HDVs
Real world emissions and energy consumption behavior from vehicles is a key element for meeting air iquality and greenhouse gas (GHG) targets for any country. While CO2 fleet targets for vehicles are defined on basis of standardized test procedures, real
Konstantin Weller +5 more
doaj +1 more source
Rock burst risk assessment of working face during open-off cut based on acoustic emission monitoring
Impact risk assessment is a work that must be carried out in driving and stoping stage in mining coal seam with impact risk to ensure the safety of driving and stoping working face.
XING Linnan
doaj +1 more source
Driving cycle for small and medium duty engine case study of Ipoh [PDF]
Driving cycles is a series of data points representing the speed of vehicle verses time sequenced profile developed for certain road, route, specific area or city.
Ab Ghafar, Fauzi
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Emission characteristics of nonmethane hydrocarbons from private cars and taxis at different driving speeds in Hong Kong [PDF]
Vehicular emissions are the major sources of a number of air pollutants including nonmethane hydrocarbons (NMHCs) in urban area. The emission composition and emission factors of NMHCs from vehicles are currently lacking in Hong Kong.
Blake, DR +4 more
core +1 more source
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
An analysis of dynamical suppression of spontaneous emission
It has been shown recently [see, for example, S.-Y. Zhu and M. O. Scully, Phys. Rev. Lett. {\bf 76}, 388 (1996)] that a dynamical suppression of spontaneous emission can occur in a three-level system when an external field drives transitions between a ...
D. A. Cardimona +20 more
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Exhaust emissions of regulated and unregulated pollutants of passenger cars [PDF]
Exhaust emissions of VOC speciation, aldehydes and other carbonyl compounds, polyaromatics and regulated pollutants are measured using a vehicle bench on a sample of passenger cars.
Andre, Jean-Marc +5 more
core +1 more source

