Results 111 to 120 of about 2,540,027 (302)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Economic Evaluation of Regional Innovative Projects in the Sphere of Biomedicine [PDF]
Журнал Сибирского федерального университета: Серия Биология, 2016 The article deals with the cost-effectiveness analysis of innovative projects in the sphere of biomedicine. The analysis of these projects makes it possible to estimate the economic benefits of the projects and will contribute to the commercialization of
Oleg N. Shishatskiy
doaj
Patent Protection, Market Uncertainty, and R&D Investment [PDF]
Real options investment theory predicts current investment falls as uncertainty about market returns increases. In the case of R&D investment, which is usually considered an irreversible form of investment, this effect should be quite pronounced.
Czarnitzki, Dirk, Toole, Andrew A.
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Análise de opções reais aplicada na diversificação da produção rural no estado do Paraná
Revista de Economia e Sociologia RuralResumo O presente artigo tem o objetivo de analisar a contribuição do uso da Teoria das Opções Reais (TOR) na análise de investimentos da diversificação da produção rural no estado do Paraná.
Wagner Dantas Souza Junior +2 more
doaj +1 more source
INCORPORATING RISK PREFERENCES INTO REAL OPTIONS MODELS [PDF]
This paper develops a framework to link the expected utility analysis to real options models in order to capture the joint effects of risk aversion and irreversibility associated with real investments.
Isik, Murat
core +1 more source
Real options with priced regime-switching risk [PDF]
, 2009 We develop a model of regime-switching risk premia as well as regimedependent factor risk premia to price real options. The model incorporates the observation that the underlying risky income streams of real options are subject to discrete shifts over ...
Driffill, John, Kenc, T., Sola, Martin
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Practical guide to real options in discrete time II [PDF]
This paper is an extended version of the paper 'Practical Guide to Real Options in Discrete Time' (http://econwpa.wustl.edu:80/eps/fin/papers/0405/0405016.pdf), where a general, computationally simple approach to real options in discrete time was ...
Sergei Levendorskii +1 more
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