Results 111 to 120 of about 2,325,720 (350)
Contrasts Between Classes of Assets in Fixed Investment Equations as a Way of Testing Real Option Theory [PDF]
This paper tests the power of real options theory to explain investment under uncertainty, exploiting differences in the degree of irreversibility between machinery and buildings.
Ciaran Driver +2 more
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Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Patent Protection, Market Uncertainty, and R&D Investment [PDF]
Real options investment theory predicts current investment falls as uncertainty about market returns increases. In the case of R&D investment, which is usually considered an irreversible form of investment, this effect should be quite pronounced.
Czarnitzki, Dirk, Toole, Andrew A.
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Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Ingenieria Industrial, 2009 Este articulo presenta los métodos actualmente disponibles para la evaluación de proyectos, dejando de manifiesto las falencias de los métodos tradicionales como el Método de Flujos de Caja Descontados, cuando son usados para evaluar proyectos con alta ...
Feliciano Alejandro Garcia Ruiz +1 more
doaj
Value creation, risk management, and real options [PDF]
The real options approach considers strategic management and decision-making as a process aimed at actively reducing exposition to downside risk and promoting exposition to upside opportunities. It stands at the hinge between pure finance and other areas
Andrey Pavlov +3 more
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Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
INCORPORATING RISK PREFERENCES INTO REAL OPTIONS MODELS [PDF]
This paper develops a framework to link the expected utility analysis to real options models in order to capture the joint effects of risk aversion and irreversibility associated with real investments.
Isik, Murat
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Economic Evaluation of Regional Innovative Projects in the Sphere of Biomedicine [PDF]
Журнал Сибирского федерального университета: Серия Биология, 2016 The article deals with the cost-effectiveness analysis of innovative projects in the sphere of biomedicine. The analysis of these projects makes it possible to estimate the economic benefits of the projects and will contribute to the commercialization of
Oleg N. Shishatskiy
doaj