Results 61 to 70 of about 29,012,891 (356)

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Strategic investment under uncertainty: merging real options with game theory [PDF]

, 2003
As becomes apparent from the standard text books in industrial organization (cf.Tirole, 1988, The Theory of Industrial Organization), the analysis of the e.ects of uncertainty within this field is yet underdeveloped.This paper shows that the new theory ...
Grzegorz Pawlina, Huisman, K.J.M.; id_orcid, Huisman, K.J.M., Pawlina, G, Thijssen, Jacco J J, Jacco Thijssen, Kort, Peter M, Thijssen, J.J.J., Kort, Peter M., Kuno J. M. Huisman, Peter M. Kort, Huisman, Kuno J M, Pawlina, G., Kort, P.M.; id_orcid, Jacco J. J. Thijssen, Kuno J.M. Huisman, Kort, P.M.   +16 more
core   +3 more sources

Integrating Real Options Analysis with long-term electricity market models

Energy Economics, 2019
In liberalized electricity markets, the investment postponement option is deemed decisive for understanding the addition of new generating capacity. Basically, it refers to the possibility for investors to postpone projects for a period while waiting for
Daniel Ríos, G. Blanco, F. Olsina
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

An Analytical Method to the Economics of Pumped Storage Power Plants Based on the Real Options Method

Energies
This paper develops an economic evaluation framework for pumped storage hydropower (PSH) projects based on real options, addressing the limitations of traditional economic evaluation methods that neglect investment flexibility and path dependence.
Weihao Wang, Jianbin Fan, Jian Le, Gong Zhang, Longxiang Chen, Lei Deng   +5 more
doaj   +1 more source

Sequencing Infrastructure Investments under Deep Uncertainty Using Real Options Analysis

, 2018
The adaptation tipping point and adaptation pathway approach developed to make decisions under deep uncertainty do not shed light on which among the multiple available pathways should be chosen as the preferred pathway.
Nishtha Manocha, V. Babovic
semanticscholar   +1 more source

Climate change and the economics of biomass energy feedstocks in semi-arid agricultural landscapes: A spatially explicit real options analysis.

Journal of Environmental Management, 2017
The economics of establishing perennial species as renewable energy feedstocks has been widely investigated as a climate change adapted diversification option for landholders, primarily using net present value (NPV) analysis. NPV does not account for key
Courtney M. Regan, J. Connor, Ramesh Raja Segaran, W. Meyer, B. Bryan, B. Ostendorf   +5 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source