Results 81 to 90 of about 613,391 (263)

Real Options in Irreversible Investment under Uncertainty: a Review

Croatian Operational Research Review, 2018
The use of real options approach to determine the optimal time to execute irreversible investment under uncertainty has been studied extensively. Several relationships between uncertainty and irreversible investment has been proposed.
Esosa Enoyoze, Sunday E. Omosigho
doaj   +1 more source

Enhancing Real Estate Project Feasibility Through Real Option Analysis

International Journal For Multidisciplinary Research
Real estate development projects are often influenced by market uncertainty, long timelines, and changing economic conditions. Traditional evaluation methods, such as Discounted Cash Flow (DCF) analysis, assume fixed future cash flows and may not fully capture the value of strategic flexibility.
kaviya V, Anisha J
openaire   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Real options theory: financial-economic assessment of projects in the ceramics industry

Revista Produção Online, 2015
The present study aimed to evaluate economically the implementation of Clean Development Mechanism in the substitution of non-renewable biomass to renewable biomass in the production process of a red ceramics enterprise.
Léony Luis Lopes Negrão, Mariana Pereira Carneiro, Jorge de Araújo Ichihara, Rubens Cardoso da Silva   +3 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A modeling government revenue guarantees in privately built transportation projects: a risk-adjusted approach

Transport, 2013
Countries around the world have welcomed Public Private Partnerships (PPPs) as an alternative to finance infrastructure. For strategic projects with high demand uncertainty, a government may decide to provide a concessionaire with a Minimum Revenue ...
Nakhon Kokkaew, Nicola Chiara
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Impact of EU Sustainability Regulations on Highest and Best Use Valuation in Real Estate

Journal of Sustainable Real Estate
This paper investigates how new EU sustainability regulations, specifically the EU Taxonomy, Corporate Sustainability Reporting Directive (CSRD), Sustainable Finance Disclosure Regulation (SFDR), and Corporate Sustainability Due Diligence Directive ...
Michaël Peeters, Ali Khan, Daan Schraven, Hilde Remøy   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source