Results 81 to 90 of about 3,743,885 (328)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Energy imbalance market call options and the valuation of storage [PDF]
arXiv, 2016 The use of energy storage to balance electric grids is increasing and, with it, the importance of operational optimisation from the twin viewpoints of cost and system stability. In this paper we assess the real option value of balancing reserve provided by an energy-limited storage unit.
arxiv
New Method for Real Option Valuation Using Fuzzy Numbers [PDF]
Real option analysis offers interesting insights on the value of assets and on the profitability of investments, which has made real options a growing field of academic research and practical application. Real option valuation is, however, often found to
Collan, Mikael
core +1 more source
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
A model for determining whether a firm should exercise multiple real options individually or simultaneously [PDF]
We develop a model for determining whether a firm should exercise two real options individually or simultaneously. The simultaneous exercise of both options has positive synergy, such as economies of scale, scope, and networks, while separate exercise of
Michi Nishihara
core
Real Options Valuation : an application to the portuguese real estate market [PDF]
, 2008 The contribution of real options analysis on the valuation of Portuguese undeveloped building sites is significant on the decision making regarding the apartment-buildings construction. Using the options model developed by Quigg (1993), and including the
Couto, Gualter +2 more
core
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
How to Proceed with Competing Alternative Energy Technologies: A Real Options Analysis [PDF]
, 2009 Afzal S. Siddiqui, Stein‐Erik Fleten
openalex +2 more sources
Real Options Analysis and Strategic Decision Making [PDF]
, 2001 Edward H. Bowman, Gary T. Moskowitz
openalex +1 more source
Diversifying Software Architecture for Sustainability: A Value-based Perspective [PDF]
arXiv, 2016 Although the concept of software diversity has been thoroughly adopted by software architects for many years, yet the advent of using diversity to achieve sustainability is overlooked. We argue that option thinking is an effective decision making tool to evaluate the trade-offs between architectural strategies and their long-term values under ...
arxiv