Results 101 to 110 of about 3,891,628 (270)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Real-World Treatment and Outcomes in ALK-Rearranged NSCLC: Results From a Large U.S.-Based Database

JTO Clinical and Research Reports
Introduction: ALK–rearranged advanced NSCLC (aNSCLC) represents 4% of all NSCLCs, and multiple ALK-targeted therapies (ALK-inhibitors) are now available for use.
Grace Chazan, M.B.B.S., BSc, FRACP, Fanny Franchini, BSc, MSc, DPhil, Roma Shah, MPH, Marliese Alexander, BPharm (Hons), MPH, PhD, Ani John, PhD, Maarten IJzerman, BSc, MSc, PhD, Benjamin Solomon, M.B.B.S., PhD, FRACP   +6 more
doaj   +1 more source

Corrigendum: Real sequence effects on the search dynamics of transcription factors on DNA. [PDF]

Sci Rep, 2015
Bauer M, Rasmussen ES, Lomholt MA, Metzler R.   +3 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

On a problem inspired by Descartes' rule of signs

Modern Mathematical Methods
We study real univariate polynomials with non-zero coefficients and with all roots real, out of which exactly two positive. The sequence of coefficients of such a polynomial begins with \(m\) positive coefficients followed by \(n\) negative followed by \(
Vladimir Kostov
doaj  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Research and implement on segmenting storage model of netflow

Tongxin xuebao, 2007
A new model was proposed to maintain sequence and ownership of netflow.This model adopted weak se-quence-based high speed data structure in memory to improve real time storage ability.In the disc level a multi-level in-dex data netflow spanning tree was ...
WU Guang-jun1, YUN Xiao-chun2, YU Xiang-zhan1, WANG Shu-peng2   +3 more
doaj   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Treatment Patterns, Prognostic Factors and Survival for ALK-Positive Advanced NSCLC In Australia: Results From the Australasian Thoracic Cancers Longitudinal Cohort Study and Biobank (AURORA)

JTO Clinical and Research Reports
Introduction: Advanced lung cancer has historically been associated with poor survival. However, with the advent of targeted therapies, outcomes are improving.
Grace Chazan, FRACP, Marliese Alexander, PhD, Fanny Franchini, PhD, Maarten IJzerman, PhD, Roma Shah, MPH, Ani John, PhD, Tim Spelman, PhD, Malinda Itchins, PhD, Nick Pavlakis, PhD, Adnan Nagrial, PhD, Lydia Warburton, FRACP, Samantha Bowyer, FRACP, Steven Kao, PhD, Sagun Parakh, PhD, Benjamin J. Solomon, PhD   +14 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source