Results 101 to 110 of about 9,000,641 (233)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Real-World Treatment and Outcomes in ALK-Rearranged NSCLC: Results From a Large U.S.-Based Database
JTO Clinical and Research ReportsIntroduction: ALK–rearranged advanced NSCLC (aNSCLC) represents 4% of all NSCLCs, and multiple ALK-targeted therapies (ALK-inhibitors) are now available for use.
Grace Chazan, M.B.B.S., BSc, FRACP +6 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Research and implement on segmenting storage model of netflow
Tongxin xuebao, 2007 A new model was proposed to maintain sequence and ownership of netflow.This model adopted weak se-quence-based high speed data structure in memory to improve real time storage ability.In the disc level a multi-level in-dex data netflow spanning tree was ...
WU Guang-jun1 +3 more
doaj +2 more sources
Ordenanza de la Junta de Gobierno y de la Suprema de Apelaciones de la Real Casa y Patrimonio
Copia digital: Real Academia de Jurisprudencia y Legislación, 2015Marca tip.
Real Casa (España)
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
On a problem inspired by Descartes' rule of signs
Modern Mathematical MethodsWe study real univariate polynomials with non-zero coefficients and with all roots real, out of which exactly two positive. The sequence of coefficients of such a polynomial begins with \(m\) positive coefficients followed by \(n\) negative followed by \(
Vladimir Kostov
doaj
Texto firmado por "Joseph Antonio Caballero"Sign.: A\b1\s-A\b4\p2\s, []\p9\sPort. con esc.
Caballero, José Antonio
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source