Results 221 to 230 of about 13,182,333 (255)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Real-World Treatment Patterns in Rheumatoid Arthritis-Associated Interstitial Lung Disease. [PDF]

ACR Open Rheumatol
Dunn JT, Matson SM, George MD, Yang Y, Roul P, Kwizerimana JD, Rojas J, Cannon GW, Sauer B, Curtis JR, Baker JF, Mikuls TR, England BR.   +12 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Oritavancin safety: a real-world pharmacovigilance study of the FAERS database. [PDF]

Front Cell Infect Microbiol
Xie B, Zhou YF, Song HC, Cui XJ.
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Repurposing Denosumab for Knee Osteoarthritis: A Real-World Signal That Now Needs a Trial. [PDF]

Int J Rheum Dis
Wei JC, Sun JS, Liu KL, Huang SW.
europepmc   +1 more source

Beyond Blind Trust in Hospital Data Warehouses: Evaluating Real-World Data Accountability. [PDF]

Learn Health Syst
Morohashi A, Yamashita S, Imaizumi T, Sano T, Kuwatsuka Y, Ando M, Shiratori Y.   +6 more
europepmc   +1 more source

A novel real-world data methodology for lymphoma outcome classification: the real-world Lugano study. [PDF]

J Comp Eff Res
Swain RS, Klink A, Asgarisabet P, Zimmerman Savill KM, Kalesan B, Balanean A, Hays H, Kaufman J, McAllister L, Omary C, Yu HT, Laney J, Richardson NC, Lerro CC, Rizvi F, Vallejo J, Wang K, Theoret MR, Rivera DR, Feinberg BA.   +19 more
europepmc   +1 more source