Results 51 to 60 of about 37,704 (263)

Religious Ethics and Moral Realism [PDF]

open access: yesاخلاق وحیانی, 2015
The purpose of this paper is to explore the relations between various forms of moral realism and some views about religious ethics, particularly, religious ethics in the Islamic tradition, although much of what is said will apply to ethical views in ...
Hajj Muhammad Legenhausen
doaj  

REALISME DALAM KEPENTINGAN NASIONAL INDONESIA MELALUI FORUM KONFERENSI ASIA AFRIKA (KAA) DAN GERAKAN NON BLOK (GNB)

open access: yesDinamika Global, 2020
Realism is an approach and paradigm that is in international relations, Realism began to be debated during World War II (World War II) because of the failure of  the League of  Nations (LBB).
Taufan Herdansyah Akbar   +2 more
doaj   +1 more source

Religious Realism vs. Anti-realism: Revisiting Don Cupitt, Paul Badham and D. Z. Phillips [PDF]

open access: yesپژوهشنامه فلسفه دین, 2016
Realism/anti-realism controversy has always been crucial in the history of philosophy, so that it has affected all philosophical areas, including religious belief, in which admitting realistic/anti-realistic approach has a wide range of influences in all
Ali Sadeqi
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Nonconceptual Content, Causal Theory, and Realism

open access: yesThe Baltic International Yearbook of Cognition, Logic and Communication, 2014
In this paper the connections between the nonconceptual content of perceptual states and realism are considered. In particular, I investigate the argument for realism that uses the notion of nonconceptual content, specifically the version proposed by ...
Błażej Skrzypulec
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

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