Results 121 to 130 of about 1,759,701 (310)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Nutzung von Mixed Reality Szenarios für Training und Service

, 2019
Virtuelle Techniken lassen sich an vielen Stellen nicht mehr aus den heutigen Arbeitsprozessen wegdenken. So ist an eine mechanische Konstruktion ohne 3D-CAD-Programm nicht mehr zu denken.
Linde, Markus, Kiesel, Markus, Beisheim, Nicolai (Prof. Dr.-Ing.)   +2 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Dynamische Geometriedatenhaltung für schnelles Rendern in effizienten Virtual Reality-Systemen

, 2022
S.169-179Der Aufsatz beschreibt die effizienten Methoden, die am IPA entwickelt worden sind, um Virtual Reality-relevante Geometriedaten schnell und umfassend hinterlegen zu können.
Däinghaus, R.
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Fusing feature consistency across views for multi-view stereo

Complex & Intelligent Systems
Dense feature matching is of significant importance in the learning-based multi-view stereo (MVS) pipeline. Feature consistency across views is a key factor affecting feature matching and plays a crucial role in the reconstruction of objects by the ...
Rong Zhao, Caiqin Jia, Xindong Guo, Xiaowen Yang, Huiyan Han, Xie Han   +5 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Tool virtualization and spatial augmented reality

This paper presents two continua for classifying and comparing the user interfaces of virtual and augmented reality systems. We are particularly interested in user interfaces consisting of physicalvirtual tools.
Marner, Michael R, Thomas, Bruce H
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Learnable Wireless Digital Twins: Reconstructing Electromagnetic Field With Neural Representations

IEEE Open Journal of the Communications Society
Wireless digital twins, which approximate the communication environment and signal propagation, find many applications in system design and operation, and are envisioned as key enablers for future wireless systems.
Shuaifeng Jiang, Qi Qu, Xiaqing Pan, Abhishek K. Agrawal, Richard Newcombe, Ahmed Alkhateeb   +5 more
doaj   +1 more source