Results 101 to 110 of about 1,718,438 (314)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Instantreality - a framework for industrial augmented and virtual reality applications

, 2022
S.78-83Rapid development in processing power, graphic cards and mobile computers open up a wide domain for Mixed Reality applications. Thereby the Mixed Reality continuum covers the complete spectrum from Virtual Reality using immersive projection ...
Behr, Johannes, Bockholt, Ulrich, Fellner, Dieter W.   +2 more
core   +1 more source

A Video-Based Cognitive Emotion Recognition Method Using an Active Learning Algorithm Based on Complexity and Uncertainty

Applied Sciences
The cognitive emotions of individuals during tasks largely determine the success or failure of tasks in various fields such as the military, medical, industrial fields, etc.
Hongduo Wu, Dong Zhou, Ziyue Guo, Zicheng Song, Yu Li, Xingzheng Wei, Qidi Zhou   +6 more
doaj   +1 more source

MiRA - mixed reality agents [PDF]

, 2011
In recent years, an increasing number of Mixed Reality (MR) applications have been developed using agent technology—both for the underlying software and as an interface metaphor.
Abraham G. Campbell, Dragone, Mauro; id_orcid, O'Hare, G. M. P. (Greg M. P.), Campbell, Abraham G., Martin, A. (Alan), Martin, Alan, Stafford, John W., Mauro Dragone, Gregory M.P. O’Hare, Holz, Thomas, Alan Martin, O'Hare, Gregory M. P., Thomas Holz, Dragone, Mauro, John W. Stafford   +14 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The impact of intraoperative optical coherence tomography on cognitive load in virtual reality vitreoretinal surgery training

Scientific Reports
Ophthalmic surgeries consist of highly demanding microsurgical tasks that require surgeons to sustain mental focus and extreme manual dexterity for extended periods.
Laura Schütz, Shervin Dehghani, Michael Sommersperger, Koorosh Faridpooya, Nassir Navab   +4 more
doaj   +1 more source

Metaverse and Digital Twins in the Age of AI and Extended Reality

Architecture
This paper explores the evolving relationship between Digital Twins (DT) and the Metaverse, two foundational yet often conflated digital paradigms in digital architecture.
Ming Tang, Mikhail Nikolaenko, Ahmad Alrefai, Aayush Kumar   +3 more
doaj   +1 more source