Results 41 to 50 of about 3,103,270 (271)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Gatekeepers of Knowledge versus Platforms of Knowledge: From Potential to Realized Absorptive Capacity [PDF]

Regional Studies, 2008
Abstract. The development of clusters rests through geographical proximity, cognitive interactions as well as entrepreneurial initiatives. Sophia-Antipolis, a multi-technology cluster, is a good illustration of the type of challenges local systems of innovation face in creating positive knowledge externalities. This paper shows that if the existence of
Longhi, Christian, Thomas, Catherine, Lazaric, Nathalie   +2 more
openaire   +3 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The impact of dynamic marketing capabilities on startup performance: A case of business incubators in Jordan [PDF]

Innovative Marketing
Dynamic marketing capabilities provide startups with the platform and market knowledge that entitle them to achieve their goals and survive the competition.
Hamza Salim Khraim
doaj   +1 more source

Creative Industry Small and Medium Enterprises, Absorption Capacity, Innovative Performance, Performance of Small and Medium Enterprises, Potential Absorptive Capacity, Realized Absorptive Capacity

International Review of Management and Marketing
This study investigates the key drivers of consumer adoption of carbon credits in the low-cost airline context in Thailand. Drawing on consumer behavior and sustainable marketing perspectives, the study examines how psychological, social, and economic factors shape passengers’ attitudes, perceived value, and behavioral intention toward carbon offset ...
Worachot Sribua, Bordin Phayaphrom, Zulfahmi Bin Rashid, Pathom Sawatmuang, Jakkawat Laphet, Duangrat Tandamrong   +5 more
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Do green dynamic capabilities and absorptive capacity affect green innovation performance? A study on companies in Indonesia

Journal of Industrial Engineering and Management
Purpose: This study aims to empirically analyze the effect of absorptive capacity, green dynamic capability, and green manufacturing practices (GMP) on green innovation performance (GIP). Design/methodology/approach: A quantitative approach was employed
Reni Amaranti, Rajesri Govindaraju, Dradjad Irianto   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

KNOWLEDGE SHARING CAPABILITY, ABSORPTIVE CAPACITY, AND INNOVATION CAPABILITY: AN EMPIRICAL STUDY OF INDONESIA’S INFORMATION AND COMMUNICATION TECHNOLOGY INDUSTRY

Journal of ICT, 2009
This research investigates the relationships between knowledge sharing capability, absorptive capacity, and innovation capability. This research proposed and tested three hypotheses.
Luciana Andrawina, Rajesri Govindaraju
doaj