Results 51 to 60 of about 1,792 (273)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Absorptive capacity, strategic flexibility, and business model innovation : Empirical evidence from Italian SMEs [PDF]

, 2021
Recognizing that business model innovation (BMI) is a constant source of value creation in the digital economy, we examine the nexus between absorptive capacity and strategic flexibility, and their effects on BMI.
De Massis, Alfredo, Miroshnychenko, Ivan, Strobl, Andreas, Matzler, Kurt   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

HUBUNGAN ANTARA KNOWLEDGE SHARING CAPABILITY, ABSORPTIVE CAPACITY DAN MEKANISME FORMAL: STUDI KASUS INDUSTRI TEKNOLOGI INFORMASI DAN KOMUNIKASI DI INDONESIA

Jurnal Teknik Industri, 2008
Knowledge is currently viewed as an important strategic resource in companies in order to gain competitive advantage. However, the success in generating competitive advantage will depend on the company’s ability to acquire and assimilate knowledge ...
Luciana Andrawina, Rajesri Govindaraju, TMA Ari Samadhi, Iman Sudirman   +3 more
doaj  

ACAP MODEL AND INNOVATION IN U-I RELATIONSHIP

Contextus, 2018
The purpose of this study is to see how the relationship between universities and companies influences the latter’s absorptive capacity and therefore competitiveness.
Raquel Engelman, Dusan Schreiber
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KNOWLEDGE SHARING CAPABILITY, ABSORPTIVE CAPACITY, AND INNOVATION CAPABILITY: AN EMPIRICAL STUDY OF INDONESIA’S INFORMATION AND COMMUNICATION TECHNOLOGY INDUSTRY

Journal of ICT, 2009
This research investigates the relationships between knowledge sharing capability, absorptive capacity, and innovation capability. This research proposed and tested three hypotheses.
Luciana Andrawina, Rajesri Govindaraju
doaj  

Do green dynamic capabilities and absorptive capacity affect green innovation performance? A study on companies in Indonesia

Journal of Industrial Engineering and Management
Purpose: This study aims to empirically analyze the effect of absorptive capacity, green dynamic capability, and green manufacturing practices (GMP) on green innovation performance (GIP). Design/methodology/approach: A quantitative approach was employed
Reni Amaranti, Rajesri Govindaraju, Dradjad Irianto   +2 more
doaj   +1 more source

Does the Size Matter for Dynamics Capabilities? A Study on Absorptive Capacity

Journal of Technology Management & Innovation, 2016
The objective of this study is to understand how organizational size influences dynamic capabilities in Brazil. To arrive at this understanding, structural equation modeling analysis was performed using the Brazilian Innovation Survey (PINTEC) database ...
Marlon Fernandes Rodrigues Alves, Jessâmine Thaise Sartorello Salvini, Ana Claudia Bansi, Elio Galli Neto, Simone Vasconcelos Ribeiro Galina   +4 more
doaj   +1 more source