Results 51 to 60 of about 20,710 (283)

International organizational performance [PDF]

Journal of Small Business and Enterprise Development, 2016
Purpose– The purpose of this paper is to analyse the relationships between congenital learning (CL) and realized absorptive capacity (RACAP) and tries to identify whether absorptive capacity impacts on international organizational performance (IOP) in today’s global business environment.Design/methodology/approach– The research model and hypothesized ...
Cegarra Navarro, Juan Gabriel, Eldridge, Stephen, Wandosell, Gonzalo   +2 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Unlocking the secrets of business intelligence and analytics in driving brand innovation: insights from an empirical study using SEM and fsQCA

Cogent Business & Management
While business intelligence and analytics (BI&A) hold significant potential for enterprise innovation, their role in driving brand innovation remains underexplored.
Zhe Xu, Xiang-Yun Xu
doaj   +1 more source

The impact of dynamic marketing capabilities on startup performance: A case of business incubators in Jordan [PDF]

Innovative Marketing
Dynamic marketing capabilities provide startups with the platform and market knowledge that entitle them to achieve their goals and survive the competition.
Hamza Salim Khraim
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

HUBUNGAN ANTARA KNOWLEDGE SHARING CAPABILITY, ABSORPTIVE CAPACITY DAN MEKANISME FORMAL: STUDI KASUS INDUSTRI TEKNOLOGI INFORMASI DAN KOMUNIKASI DI INDONESIA

Jurnal Teknik Industri, 2008
Knowledge is currently viewed as an important strategic resource in companies in order to gain competitive advantage. However, the success in generating competitive advantage will depend on the company’s ability to acquire and assimilate knowledge ...
Luciana Andrawina, Rajesri Govindaraju, TMA Ari Samadhi, Iman Sudirman   +3 more
doaj  

ACAP MODEL AND INNOVATION IN U-I RELATIONSHIP

Contextus, 2018
The purpose of this study is to see how the relationship between universities and companies influences the latter’s absorptive capacity and therefore competitiveness.
Raquel Engelman, Dusan Schreiber
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source