Results 111 to 120 of about 178,419 (318)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Abundance of juvenile coho salmon in Oregon coastal streams
, 2000 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.1998 and 1999Mode of access: Internet from the Oregon ...
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Nursery- vs. Mother-Reared Baboons: Reproductive Success and Health Parameters
Veterinary SciencesThere is a plethora of data demonstrating the deleterious consequences of nursery rearing in nonhuman primates (NHPs). However, baboon studies report varying consequences of nursery rearing, from no differences in reproduction and sociality to moderate ...
Sarah J. Neal +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2012 Mortality is a major concern in larval fish rearing during exogenous feeding. An important cause of mortality of larval yellowtail kingfish (Seriola lalandi) during the rotifer - Artemia weaning period was hypothesised as being due to larval sinking ...
Partridge, G.J. +2 more
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Journal of Veterinary Research, 2016 Introduction: This article presents the analysis of the correlation between the category and health status of calves and the results of their rearing and levels of selected blood parameters.
Wielgosz-Groth Zofia +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Artificial propagation of milkfish: Present status and problems
, 1984 Milkfish (Chanos chanos ) has been extensively cultured in Indonesia, Taiwan, and the Philippines. At present, the only source of fry for fish farmers is the coastal waters during the spawning season.
Lam, T. J.
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, 2019 Cognitive-behavioural models of obsessive-compulsive disorder (OCD) propose that inflated responsibility beliefs are central to the maintenance of the disorder and are proposed to originate during early childhood via experiences of harsh and/or ...
Waters, Allison M +4 more
core +1 more source