Results 81 to 90 of about 545,522 (315)
Rearrangement and evolution of mitochondrial genomes in parrots
Molecular Phylogenetics and Evolution, 2015 Mitochondrial genome rearrangements that result in control region duplication have been described for a variety of birds, but the mechanisms leading to their appearance and maintenance remain unclear, and their effect on sequence evolution has not been ...
J. Eberhard, T. Wright
semanticscholar +1 more source
Epilepsia, 2005 Summary: The immature brain is highly susceptible to seizures. The heightened susceptibility to seizures appears to be due, at least in part, to developmental changes that skew the balance between excitatory and inhibitory neurotransmitter systems in the brain in favor of a state of excitation.
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2013 Oxidative cyclization of 6-chloro-4-pyrimidinylhydrazones 4 with iodobenzene diacetate (IBD) in dichloromethane gives rise to [1,2,4]triazolo[4,3-c]pyrimidine derivatives 5a–o.
Caifei Tang, Zhiming Li, Quanrui Wang
doaj +1 more source
Next-Generation Sequencing Technologies for Early-Stage Cutaneous T-Cell Lymphoma
Frontiers in Medicine, 2019 The diagnosis of early stage cutaneous T-cell lymphoma is often difficult, particularly in mycosis fungoides (MF), because the clinical presentation, histological findings, and laboratory findings of MF resemble those of inflammatory skin diseases such ...
Kazuyasu Fujii, Takuro Kanekura
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Beilstein Journal of Organic ChemistryA skeletal rearrangement of a series of 6,8-dioxabicyclo[3.2.1]octan-4-ols has been developed using SOCl2 in the presence of pyridine. An oxygen migration from C5 to C4 was observed when the C4 alcohols were treated with SOCl2/pyridine, giving a 2-chloro-
Martyn Jevric +5 more
doaj +1 more source
A survey of anesthesiologists aged 60 years and older in Korea: current status, challenges, and future strategies [PDF]
Anesthesia and Pain MedicineBackground As the global population ages, medical professionals are also aging. This study investigates the status of Korean anesthesiologists over the age of 60. Methods Anesthesiologists aged 60 and older, residing and working in Korea, were invited to
Won Uk Koh +8 more
doaj +1 more source
REARRANGEMENT OF CRLF2 IN B-PROGENITOR AND DOWN SYNDROME ASSOCIATED ACUTE LYMPHOBLASTIC LEUKEMIA
Nature Genetics, 2009 Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here we report a recurring interstitial deletion of the pseudoautosomal region 1
C. Mullighan +23 more
semanticscholar +1 more source