Results 151 to 160 of about 3,262,397 (309)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Trust as the End of Practical Reason. Justification Procedures

, 2012
This paper is about the epistemology of practical reason and, in particular, the function of trust as an end to be pursued rationally in praxis. Our purpose is threefold: first, to present an outline of the structure of practical reason; secondly, to ...
Giordani, Alessandro, Gomarasca, Paolo
core  

Specific Cultural Myths Impacting Antipsychotic Drug Adherence: Reclaiming Healthy Thinking Through Emotional Recovery. [PDF]

Schizophr Bull Open
Ryan SM.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Good and Evil in the Interior Voluntary Act : S.T.I-II,q,19

, 2002
P(論文)In the Summa Theologiae, I-II, q.19, Thomas Aquinas discusses good and evil in the interior voluntary act. According to Thomas, man's will is moved by the object, which his intellect presents to it.
OHARA, Taku, 113, オハラ, タク, 小原, 琢   +3 more
core  

Correction: Bhattarai et al. Characterisation of a 4A QTL for Metribuzin Resistance in Wheat by Developing Near-Isogenic Lines. <i>Plants</i> 2021, <i>10</i>, 1856. [PDF]

Plants (Basel)
Bhattarai R, Liu H, Siddique KHM, Yan G.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Learning for nurses from a cross-sectional quantitative analysis of youth engagement in an emergency department-based violence reduction scheme. [PDF]

J Res Nurs
Cook G, Walter K, Reed K, Bekaert S.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Revision and re-revision after mobile- and fixed-bearing lateral unicompartmental knee arthroplasty. [PDF]

Int Orthop
Göktepe MC, Martin J, Mohr G, Hariri M, Clarius M.   +4 more
europepmc   +1 more source