Results 81 to 90 of about 3,262,397 (309)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Ulrike Müßig – Reason and Fairness

, 2020
A review essay of the book: Ulrike Müßig, Reason and Fairness.
Thomas Hoeren
core   +1 more source

Political Knowledge: Measurement, Elitism, and Dogmatism [PDF]

Public Reason
Political knowledge is a resource: having a lot of it means being in a position to navigate the political world, and stand a better chance of connecting your fundamental political goals with successful means.
Kristoffer Ahlstrom-Vij
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Living Inquiry: Personal, political and philosophical groundings of Action Research Practice

, 2008
This chapter seeks to detail the scholarly and intellectual threads identified by members of the action research community, and to point to further reading for those interested in pursuing these.
Bradbury, H., Reason, P., Gaya Wicks, PC
core  

Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires

Biology Direct, 2006
It has been suggested that codon insertion and/or deletion may represent a mechanism that, along with hypermutation, contributes to the affinity maturation of antibodies.
Zhou Jianhui, Reason Donald C
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Archive, Empathy, Memory: The Resurrection of Joyce Reason

, 2016
This paper uses the prism of archival, ancestral research to consider the nature of our relationship to the lives of the Others that we find in the past.
Reason, Matthew
core  

A Defence of a Rationalist Conception of Practical Reason

European Journal of Analytic Philosophy, 2017
In this paper I attempt to refute the instrumental conception of practical reason, and thus defend a rationalist conception of practical reason. I argue that, far from merely playing an instrumental role, reason can be used by an agent to evaluate, that ...
Gal Yehezkel
doaj   +1 more source