Results 91 to 100 of about 3,703,656 (252)

Ulrike Müßig – Reason and Fairness

, 2020
A review essay of the book: Ulrike Müßig, Reason and Fairness.
Thomas Hoeren
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Significance of Deep Disagreements on Justice, Values, and Morals for Political Epistemology [PDF]

Public Reason
Political epistemology asks whether there is knowledge about values, the good, the just, and the morally right that could be applied to political issues. Debates on such questions go back to the ancient Greeks. While Protagoras claims that no moral facts
Manuel Knoll
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Rules, Reason and Self-Knowledge

, 2014
The review presents and critically discusses Julia Tanney's "Rules, reason and self-knowledge"
COLIVA, Annalisa
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Nonsense and the General Form of the Sentence [PDF]

Public Reason
In his paper ‘The Bounds of Nonsense’ Adrian Moore defines sentences for Wittgenstein’s Tractatus as those items to which truth-operations apply, and understands this as a disjunctivist theory.
Michael Morris
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Epistemological Issues in the Theory of Equality of Opportunity [PDF]

Public Reason
EOp (Equality of opportunity) is an algorithm for measuring the degree of opportunity equality in a society. The researcher must identify the kind of advantage of concern (e.g., income , life expectancy, wage earning capacity), and what circumstances ...
John E. Roemer
doaj