Results 101 to 110 of about 3,262,397 (309)

Introduction [PDF]

Public Reason
Introduction
Jakub Szczepanski
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

"The Sleep of Reason:" A Video Installation by Bill Viola

, 1991
Photograph of the exhibition "'The Sleep of Reason:' A Video Installation by Bill Viola," November 14, 1991-February 9, 1992 held at the Dallas Museum of ...
Dallas Museum of Art
core   +2 more sources

The Significance of Deep Disagreements on Justice, Values, and Morals for Political Epistemology [PDF]

Public Reason
Political epistemology asks whether there is knowledge about values, the good, the just, and the morally right that could be applied to political issues. Debates on such questions go back to the ancient Greeks. While Protagoras claims that no moral facts
Manuel Knoll
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Review of Rodney A. Brooks : Intelligence Without Reason

, 1998
This paper will provide an overview of Rodney A. Brooks' Intelligence Without Reason, followed by a discussion of Oren Etzioni's and Michael Coen's critiques of the paper. Finally, my own thoughts will conclude the report.
Eric Benzacar, A. Brooks, Intelligence Without Reason   +2 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Adherence to anti-Parkinson drug therapy in the "REASON" sample of Italian patients with Parkinson's disease: the linguistic validation of the Italian version of the "Morisky Medical Adherence scale-8 items"

, 2013
Information about patients’ adherence to therapy represents a primary issue in Parkinson’s disease (PD) management. To perform the linguistic validation of the Italian version of the self-rated 8-Item Morisky Medical Adherence Scale (MMAS-8) and to ...
Antonini A., Ceravolo R., TINAZZI, Michele, Morisky D. E., Abbruzzese G., Castegnaro G., Barone P., Fabbrini G., On behalf of the REASON study group, Rizzoli S., Lessi P.   +10 more
core   +1 more source

Nonsense and the General Form of the Sentence [PDF]

Public Reason
In his paper ‘The Bounds of Nonsense’ Adrian Moore defines sentences for Wittgenstein’s Tractatus as those items to which truth-operations apply, and understands this as a disjunctivist theory.
Michael Morris
doaj