Results 91 to 100 of about 2,478,107 (298)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cooperation, fairness and team reasoning

, 2021
This paper examines two strands of literature regarding economic models of cooperation. First, payoff transformation theories assume that people may not be exclusively motivated by self-interest, but also care about equality and fairness.
Duijf, Hein; id_orcid, Duijf, Hein
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Working memory capacity and fluid abilities: The more difficult the item, the more more is better

Frontiers in Psychology, 2014
The relationship between fluid intelligence and working memory is of fundamental importance to understanding how capacity-limited structures such as working memory interact with inference abilities to determine intelligent behaviour.
Daniel R Little, Stephan eLewandowsky, Stephan eLewandowsky, Stewart eCraig   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Assessing a virtual scenario-based training system for enhancing clinical reasoning and communication in dental education

BMC Oral Health
Background This study aims to assess the effectiveness of a virtual scenario-based clinical reasoning training system to improve clinical reasoning and communication skills among dental students.
Ye Cao, Siyang Yuan, Yongchu Pan, Zixin Yan, Zhendong Wang, Zhaolan Guan, Luwei Liu, Bin Yan   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Reasoning skills and Reading [PDF]

, 2020
The current investigation aims to provide new scientific evidence associated with reasoning skills in adults and children, and more specifically, to look into the relationship between reasoning and reading skills in adults and children with typical ...
Panagiotidou, Elpida
core   +1 more source

Learning clinical reasoning skills during the transition from a medical graduate to a junior doctor

The Asia Pacific Scholar
Introduction: The literature confirms the challenges of learning clinical reasoning experienced by junior doctors during their transition into the workplace.
WCD Karunaratne, Madawa Chandratilake, Kosala Marambe   +2 more
doaj   +1 more source