Results 161 to 170 of about 2,478,107 (298)

Reasoning about hybrid reasoning : a discussion [PDF]

In this discussion we outline an approach to reasoning about hybrid reasoning systems. We believe that following this approach allows theoretical results to be obtained rapidly, allows a high level of understanding about the relationship between ...
Gent, Ian, Cohn, A. G.
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Training medical students' diagnostic reasoning skills using multivariate analysis. [PDF]

BMC Med Educ
Schaberle FA, Pestana J, Santiago LM, Pais AACC.   +3 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Impact of problem-based learning on the development of clinical reasoning skills in esophageal cancer teaching. [PDF]

Medicine (Baltimore)
Zhao L, He J, Han Z, Zhang Y, Li L.
europepmc   +1 more source

Complexity Results and Algorithms for Preferential Argumentative Reasoning in ASPIC+

We provide complexity results and algorithms for reasoning in the central structured argumentation formalism of ASPIC+. Considering ASPIC+ accommodated with preferences under the last-link principle, the results are made possible by rephrasing several ...
Järvisalo, Matti, Odekerken, Daphne, Wallner, Johannes P., Lehtonen, Tuomo   +3 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Keeping In-the-Loop: Supporting Clinical Reasoning Skills for Nephrology Learners in the Age of Artificial Intelligence. [PDF]

Clin J Am Soc Nephrol
Boyle SM, Parsons AS, Sozio SM, Chan L, Warburton KM.   +4 more
europepmc   +1 more source

Sociomoral Reasoning Skills during Childhood: A Comprehensive and Predictive Approach. [PDF]

Brain Sci, 2022
Morasse F, Bernier A, Lalonde G, Hétu S, Beauchamp MH.   +4 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source