Results 201 to 210 of about 2,478,107 (298)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Better understanding the clinical reasoning skills of 4th-year medical students through think aloud interviews: implications for theory and practice. [PDF]

Adv Health Sci Educ Theory Pract
Cuddy MM, Runyon C, Luciw-Dubas UA, Iaccarino S, Somay S, Lord J, Swym R, Harik P.   +7 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Using Peer-Assisted Learning to Enhance Clinical Reasoning Skills in Undergraduate Nursing Students: A Study in Iraq. [PDF]

Adv Med Educ Pract
Hamarash MQ, Ibrahim RH, Yaas MH, Almushhadany OI, Al Mukhtar SH.   +4 more
europepmc   +1 more source

Evaluation of Moral Reasoning Skills among Dental Students in the Makkah Region, Saudi Arabia.

J Pharm Bioallied Sci, 2023
Al-Subaihi SA, Al-Jifree HM, Abuznadah WT, Agou SH.   +3 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Enhancing clinical reasoning skills in medical students through team-based learning: a mixed-methods study. [PDF]

BMC Med Educ
Ishizuka K, Shikino K, Takada N, Sakai Y, Ototake Y, Kobayashi T, Inoue T, Jikuya R, Iwata Y, Nishimura K, Yoshimi R, Oi Y, Watanabe Y, Togashi Y, Ogawa F, Sano D, Asami T, Imai Y, Takeuchi I, Funakoshi K, Ohta M, Inamori M, Kusakabe A.   +22 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Using diagnostic reasoning (DxR) to teach and evaluate clinical reasoning skills

Academic Medicine, 1994
J H, Myers, J K, Dorsey
openaire   +3 more sources