Results 81 to 90 of about 166,784,693 (289)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Assessing the EU's conflict prevention and peacebuilding interventions in Ukraine

, 2017
The Case Study Report on Ukraine was produced as part of the project “Whole-of-Society Conflict Prevention and Peacebuilding” (WOSCAP). It contains the research findings on the EU’s interventions in conflict prevention and peacebuilding in Ukraine.
Kateryna Zarembo, Leonid Litra, Zarembo, Kateryna, Litra, Leonid, Ivan Medynskyi, Medynskyi, Ivan   +5 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The Metaphysics of Reasons

, 2018
This chapter focuses exclusively on normative reasons. Normative reasons count in favor of actions and attitudes like beliefs, desires, feelings, and emotions. Section 11.2 explores the common ground concerning the metaphysics of reasons.
Olson, Jonas,, Olson, Jonas
core   +1 more source

“This Scandal Could Last for Months”. Stages and Outcome of the Conflict of G.P. Fedotov with the Board of St. Sergius Orthodox Institute in Paris in 1939

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2018
Introduction. The paper investigates the stages and outcome of the conflict of Georgy Fedotov with the Board of the Orthodox Institute in Paris (first half of 1939). Methods and materials. The paper focuses on the published materials of G.
Anton A. Voytenko
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Conflict, Disasters, and No Jobs: Reasons for International Migration from Sub-Saharan Africa [PDF]

Sub-Saharan Africa (SSA) has the highest growth rate in net international migration in the world. The reasons for this migration are investigated in this paper.
Naude, Wim
core  

JUSTIFIKASI INTERVENSI INTERNASIONAL DALAM KONFLIK SUATU NEGARA

Jurnal Asia Pacific Studies, 2017
Conflict among states or interstate conflict is still part of the important concern in the politics and international relations. International attention is becoming stronger along with the shift view of international society regarding the intervention ...
Andaru Satnyoto
doaj