Results 101 to 110 of about 166,784,693 (289)
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Breves consideraciones en torno a la reacción pagana: 384- 410 a. D
Studia Historica: Historia Antigua, 2010 SUMMARY: The pagan-christian conflict from second middle fourth century a.D. onward presents us the problema about the reasons that impel to these last pagans to defend the traditional ideals. The battle in favour of the survival against the implantation
María PÉREZ MEDINA
doaj
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Nordic Wittgenstein Review, 2014 My paper reflects on the debate about reasons for action and action explanations between Wittgensteinian teleological approaches and causalist theories inspired by Davidson.
Hans-Johann Glock
doaj
Ripeness Levels and Their Relations with the Success of the Negotiation Method: CPP-NPA, TTP, IRA
Gazi Akademik Bakış, 2023 Conflict arises for a variety of reasons. Parties may fail to achieve clear success in the conflict process and achieve their goals. In such a situation, conflict causes the parties to reach the mutually hurting stalemate.
Emrah KAYA
doaj
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Individual differences in response to goal conflict: impact of causality orientations on goal progress and emotional well-being during goal conflict [PDF]
, 2017 Goal progress and attainment of important personal goals is related to higher well-being. Obstacles in goal progress, such as holding multiple, conflicting goals, can lead to a negative change in well-being.
Hoet, Ariana C. +1 more
core
Conflicting reasons, unconflicting ‘ought’s
Philosophical Studies, 2015 One of the popular albeit controversial ideas in the last century of moral philosophy is that what we ought to do is explained by our reasons. And one of the central features of reasons that accounts for their popularity among normative theorists is that they can conflict.
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source