Results 111 to 120 of about 785,607 (304)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Letters From Batticaloa : TMVP's Emergence and the Transmission of Conflict in Eastern Sri Lanka
, 2013 In March 2004 a man known as Karuna Amman announced his defection from the LTTE (Liberation Tigers of Tamil Eelam), an armed group seeking the formation of an independent Tamil state in the north and east of Sri Lanka.
Political Conflict, Cultural Trauma and Social Reconstruction +2 more
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Consequences of Reasoning with Conflicting Obligations
Mind, 2014 Since at least the 1960s, deontic logicians and ethicists have worried about whether there can be normative systems that allow conflicting obligations. Surprisingly, however, little direct attention has been paid to questions about how we may reason with conflicting obligations.
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Development and Conflict: The Economic Impacts of Civil War in Swat: Pakistan
, 2015 Violent conflicts have economic causes and economic consequences. In addition to the lost lives, injuries and the overall scale of human suffering that conflicts create, they also destroy assets and institutions.
Bhatti, Haseeb Ahmed
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A comparative study of teachers' and secondary level pupils' perceptions of, and responses to conflict in England and Denmark [PDF]
This study examined the perceptions of and responses to conflict of pupils and teachers in secondary schools in England and Denmark. It also examined the responses of schools to pupil conflicts and whether pupils and teachers found these measures to ...
Afnan-Rizzuto, Kamilya
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Reasons and Victims of Honour Killing in Pakistan: An Analysis
, 2023 Honour killing in Pakistan is a very critical issue which is being echoed throughout the world. Parallel to it are the governmental claims that this issue has been addressed, by enhancing the representation in the legislature assemblies and by the strict
Ishtiaq Ahmad Choudhry; Professor of International Relations Lahore Garrison University, Lahore. +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source