Results 111 to 120 of about 166,784,693 (289)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Death certificate: S. A. Reasons

, 1917
This is a photograph of the death certificate for S. A. Reasons, deceased on 1917-12-05, filed with the Arkansas Department of Health by the Ruebel Funeral Home in Little Rock.Transcribed.
Ruebel Funeral Home (Little Rock, Ark.)
core  

Reasons for Belief and Normativity

, 2018
In this chapter, we critically examine the most important extant ways of understanding and motivating the idea that reasons for belief are normative. First, we examine the proposal that the distinction between explanatory and so-called normative reasons ...
Glüer, Kathrin,, Glüer, Kathrin, Wikforss, Åsa, Wikforss, Åsa,   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Women’s Role in Violence and UN Women, Peace, and Security Agenda

Alternatif Politika
The UN’s Women, Peace, and Security (WPS) agenda emphasizes women’s victimhood and peacemaking roles. However, women participate in two-thirds of armed movements and affect conflict outcomes in unique gendered ways.
Çağlayan Başer
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Discussing the EU’s Conflict Prevention and Peacebuilding Capabilities in Ukraine: Report from the Kyiv policy roundtable

The roundtable discussion of WOSCAP policy recommendations presented by the Institute of World Policy, took place on 6 June 2017 in Kyiv, Ukraine.
Association of Middle Eastern Studies (AMES) & Global Partnership for the Prevention of Armed Conflict (GPPAC)
core   +1 more source

Forces of Destruction and Construction : Local Conflict Dynamics, Institutional Trust and Postwar Crime

, 2018
In 2017 alone, an estimated 68,851 people lost their lives as a consequence of civil wars, that is, armed conflicts that take place within the borders of a state.
Deglow, Annekatrin
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Conflict in Abkhazia: Reasons and Solutions

, 2019
Abkhazia is a breakaway region of Georgia with 240, 000 population (Freedom House. 2018). Ethnic Abkhazians firstly expanded over western Georgia in the ninth century and soon integrated in Sakartvelo with ethnic Georgians. There were no any interstate disputes between Abkhazians and Georgians during long-term history.
openaire   +1 more source