Results 61 to 70 of about 22,607 (211)

Attenuation of Influenza a Virus into Live Vaccines Through C‐End Degrons

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Naturally occurring C‐end degrons are exploited to design proteolysis‐targeting live attenuated influenza vaccines. C‐end degron tagging of viral M1 protein promotes proteasome‐dependent degradation, resulting in robust attenuation in host cells while permitting scalable production in engineered cells.
Ping Wang, Le Li, Yunfang Chen, Le Tong, Zhen Li, Rong Yu, Quan Shen, Qikai Wang, Jihuan Hou, Qisi Zhang, Xu Si, Ning Wang, Demin Zhou, Wen‐xia Tian, Longlong Si   +14 more
wiley   +1 more source

Rotavirus Vaccine Breakthrough With Vaccine‐Modified Disease in a Sibling Cluster of Equine‐Like G3P[8] Infection

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Rotavirus remains one of the major causes of childhood gastroenteritis despite the widespread introduction of rotavirus vaccines. Here, we report a sibling cluster of three children hospitalized with fever, vomiting, and diarrhea. Two unvaccinated siblings (11 years 9 months and 10 years 1 month) developed severe gastroenteritis with profuse ...
Ahmad Syatir Tahar, Eng Joe Ong, Dewi Mamora, Cheng Siang Tan   +3 more
wiley   +1 more source

Whole-Genome Phylogenetic Analysis of Influenza B/Phuket/3073/2013-Like Viruses and Unique Reassortants Detected in Malaysia between 2012 and 2014.

PLoS ONE, 2017
Reassortment of genetic segments between and within influenza B lineages (Victoria and Yamagata) has been shown to generate novel reassortants with unique genetic characteristics.
Xiang Yong Oong, Kim Tien Ng, Joon Ling Tan, Kok Gan Chan, Adeeba Kamarulzaman, Yoke Fun Chan, I-Ching Sam, Kok Keng Tee   +7 more
doaj   +1 more source

Development and Qualification of a Pseudotyped Virus‐Based Microneutralisation Assay for Influenza D Virus

Influenza and Other Respiratory Viruses, Volume 20, Issue 4, April 2026.
ABSTRACT Background Epidemiological surveillance of influenza D virus (IDV) has gained increased priority following recent serological findings indicating its potential zoonosis in humans. In this context, it is crucial to develop strong, reproducible, reliable and scalable immunological assays that can be quickly implemented in the surveillance of new
Maria Giovanna Marotta, Tobias Mapulanga, Meshach Maina, Janet Daly, Michele Camero, Pauline Mvan Diemen, Helen E. Everett, Emanuele Montomoli, Kelly da Costa, Nigel Temperton, Claudia Maria Trombetta   +10 more
wiley   +1 more source

Reassortant human group C rotaviruses in Hungary [PDF]

Infection, Genetics and Evolution, 2015
This is the first study from Europe to report the occurrence of reassortant human RVCs bearing the genetic backbone of the Asian lineage of human RVCs. The introduction of this newly described human RVC lineage in Hungary was accompanied with reassortment involving the NSP4 gene.
Marton, Szilvia, Deák, Judit, Dóró, Renáta, Csata, Tünde, Farkas, Szilvia L., Martella, Vito, Bányai, Krisztián   +6 more
openaire   +3 more sources

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, Volume 13, Issue 14, 9 March 2026.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment [PDF]

, 2013
Influenza A virus (IAV) has a segmented genome that allows for the exchange of genome segments between different strains. This reassortment accelerates evolution by breaking linkage, helping IAV cross species barriers to potentially create highly ...
Zeldovich, Konstantin B., Liu, Ping, Renzette, Nicholas, Foll, Matthieu, Pham, Serena T., Venev, Sergey V., Gallagher, Glen R., Bolon, Daniel N., Kurt-Jones, Evelyn A., Jensen, Jeffrey D., Caffrey, Daniel R., Schiffer, Celia A., Kowalik, Timothy F., Wang, Jennifer P., Finberg, Robert W.   +14 more
core   +1 more source

Potential for La Crosse virus segment reassortment in nature

Virology Journal, 2008
The evolutionary success of La Crosse virus (LACV, family Bunyaviridae) is due to its ability to adapt to changing conditions through intramolecular genetic changes and segment reassortment.
Geske Dave, Blair Carol D, Blitvich Bradley J, Reese Sara M, Beaty Barry J, Black William C   +5 more
doaj   +1 more source

Complete analysis of the H5 hemagglutinin and N8 neuraminidase phylogenetic trees reveals that the H5N8 subtype has been produced by multiple reassortment events [PDF]

, 2016
The analysis of the complete H5 hemagglutinin and H8 neuraminidase phylogenetic trees presented in this paper shows that the H5N8 avian influenza has been generated by multiple reassortment events.
A Dalby, A Dalby, A Dalby, A Rambaut, C Adlhoch, D Alexander, D Lee, F Matsen, G Smith, H Ip, H Shimodaira, H Wu, H Yoon, J Brown, J Jeong, J Pasick, J Verhagen, K Ku, K Tamura, M Jhung, M Price, R Squires, X Xu, Y Bao, Y Lee   +24 more
core   +1 more source

Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

Advanced Genetics, Volume 7, Issue 1, March 2026.
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man, Lin Du, Ying Liu, Zehan Pang, Hongyan Zhu, Bixia Hong, Zhichao Xu, Huahao Fan   +7 more
wiley   +1 more source