Results 51 to 60 of about 15,600 (199)

Widespread Reassortment Shapes the Evolution and Epidemiology of Bluetongue Virus following European Invasion.

PLoS Pathogens, 2015
Genetic exchange by a process of genome-segment 'reassortment' represents an important mechanism for evolutionary change in all viruses with segmented genomes, yet in many cases a detailed understanding of its frequency and biological consequences is ...
Kyriaki Nomikou, Joseph Hughes, Rachael Wash, Paul Kellam, Emmanuel Breard, Stéphan Zientara, Massimo Palmarini, Roman Biek, Peter Mertens   +8 more
doaj   +1 more source

influenza-global-reassortment: Post-peer review release [PDF]

, 2016
<p>In this release, there are updated notebooks and figures that were added in response to the comments provided by our two very constructive reviewers.
Eric Ma
core   +1 more source

In Vitro Reassortment between Endemic Bluetongue Viruses Features Global Shifts in Segment Frequencies and Preferred Segment Combinations

Microorganisms, 2021
Bluetongue virus (BTV) is an arthropod-borne pathogen that is associated with sometimes severe disease in both domestic and wild ruminants. Predominantly transmitted by Culicoides spp.
Jennifer Kopanke, Justin Lee, Mark Stenglein, Christie Mayo   +3 more
doaj   +1 more source

Inferred reassortment rate across all individuals. [PDF]

, 2017
BIC values from the MGML model, relative to the optimal value, for the early-treatment, standard-treatment, and combined datasets. Horizontal dashed lines indicate the relative BIC value given rapid reassortment between segments.
Ashley Sobel Leonard (2738740), Christopher W. Woods (104194), Xudong Lin (88866), Amy Ransier (3723697), David E. Wentworth (422363), Micah T. McClain (200348), Suman R. Das (236651), Anthony S. Gilbert (444037), Christopher J. R. Illingworth (108200), Katia Koelle (82611), Gavin J. D. Smith (150548), Rob Lambkin-Williams (444042), Rebecca A. Halpin (177954), Geoffrey S. Ginsburg (104197), Timothy B. Stockwell (249318)   +14 more
core   +1 more source

Terminal reassortment drives the quantum evolution of type III effectors in bacterial pathogens. [PDF]

PLoS Pathogens, 2006
Many bacterial pathogens employ a type III secretion system to deliver type III secreted effectors (T3SEs) into host cells, where they interact directly with host substrates to modulate defense pathways and promote disease.
John Stavrinides, Wenbo Ma, David S Guttman   +2 more
doaj   +1 more source

Genetic Evolution of Avian Influenza A (H9N2) Viruses Isolated from Domestic Poultry in Uganda Reveals Evidence of Mammalian Host Adaptation, Increased Virulence and Reduced Sensitivity to Baloxavir

Viruses, 2022
A (H9N2) avian influenza A viruses were first detected in Uganda in 2017 and have since established themselves in live bird markets. The aim of this study was to establish the subsequent genetic evolution of H9N2 viruses in Uganda.
Gladys Atim, Titus Tugume, Qouilazoni A. Ukuli, Bernard Erima, Andrew Mubiru, Hannah Kibuuka, Edison Mworozi, Pamela McKenzie, Jasmine C. M. Turner, David Walker, Trushar Jeevan, Robert G. Webster, Jeremy Jones, Richard J. Webby, Mariette F. Ducatez, Fred Wabwire-Mangen, Denis K. Byarugaba   +16 more
doaj   +1 more source

Evolution of Avian Influenza Virus (H3) with Spillover into Humans, China

Emerging Infectious Diseases, 2023
The continuous evolution of avian influenza viruses (AIVs) of subtype H3 in China and the emergence of human infection with AIV subtype H3N8 highlight their threat to public health.
Jiaying Yang, Ye Zhang, Lei Yang, Xiyan Li, Hong Bo, Jia Liu, Min Tan, Wenfei Zhu, Yuelong Shu, Dayan Wang   +9 more
doaj   +1 more source

Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife

Biological Reviews, EarlyView.
ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief, Sandra Bouwhuis, Anja Globig, Anne Günther, Wouter Courtens   +4 more
wiley   +1 more source

Whole-Genome Analyses Identifies Multiple Reassortant Rotavirus Strains in Rwanda Post-Vaccine Introduction

Viruses, 2021
Children in low-and middle-income countries, including Rwanda, experience a greater burden of rotavirus disease relative to developed countries. Evolutionary mechanisms leading to multiple reassortant rotavirus strains have been documented over time ...
Sebotsana Rasebotsa, Jeannine Uwimana, Milton T. Mogotsi, Kebareng Rakau, Nonkululeko B. Magagula, Mapaseka L. Seheri, Jason M. Mwenda, M. Jeffrey Mphahlele, Saheed Sabiu, Richard Mihigo, Leon Mutesa, Martin M. Nyaga   +11 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source