Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus [PDF]
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the reasons for its unusual severity among young adults.
A. Rambaut +29 more
core +2 more sources
Widespread recombination, reassortment, and transmission of unbalanced compound viral genotypes in natural arenavirus infections. [PDF]
Arenaviruses are one of the largest families of human hemorrhagic fever viruses and are known to infect both mammals and snakes. Arenaviruses package a large (L) and small (S) genome segment in their virions.
Chang, Li-Wen +13 more
core +3 more sources
Predicting Avian Influenza Co-Infection with H5N1 and H9N2 in Northern Egypt. [PDF]
Human outbreaks with avian influenza have been, so far, constrained by poor viral adaptation to non-avian hosts. This could be overcome via co-infection, whereby two strains share genetic material, allowing new hybrid strains to emerge. Identifying areas
Ali, Mohamed A +5 more
core +2 more sources
Intrahost Dynamics of Influenza Virus Reassortment [PDF]
ABSTRACT The segmented nature of the influenza virus genome allows reassortment between coinfecting viruses. This process of genetic exchange vastly increases the diversity of circulating influenza viruses. The importance of reassortment to public health is clear from its role in the emergence of a number of epidemiologically ...
Hui, Tao, John, Steel, Anice C, Lowen
openaire +2 more sources
Intrasubtype reassortments cause adaptive amino acid replacements in H3N2 influenza genes. [PDF]
Reassortments and point mutations are two major contributors to diversity of Influenza A virus; however, the link between these two processes is unclear.
Alexey D Neverov +3 more
doaj +1 more source
Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine [PDF]
Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine ...
A. L. Vincent +58 more
core +2 more sources
Reassortant viruses threatening fish aquaculture
AbstractAquaculture provides more than half of fish destined for human consumption worldwide. In aquaculture, infectious diseases triggered by viruses are amongst the major cause of mortality of farmed fish. The cohabitation of different virus strains in the same geographical area opens the possibility to natural reassortment.
Yulema Valero, Alberto Cuesta
openaire +1 more source
Serological characterization of human reassortant rotaviruses [PDF]
We analyzed the serological properties of two human wild-type cell culture-adapted rotaviruses (strains 308 and 46) and of 308 X 46 reassortants which were previously obtained and genetically characterized. Strain 308, exhibiting a so-called long RNA pattern, was found to belong to human rotavirus subgroup II, serotype 1, whereas strain 46, exhibiting ...
Garbarg-Chenon, A. +2 more
openaire +3 more sources
Reassortment between Avian H5N1 and Human Influenza Viruses Is Mainly Restricted to the Matrix and Neuraminidase Gene Segments [PDF]
Highly pathogenic avian influenza H5N1 viruses have devastated the poultry industry in many countries of the eastern hemisphere. Occasionally H5N1 viruses cross the species barrier and infect humans, sometimes with a severe clinical outcome.
Bestebroer, T.M. (Theo) +5 more
core +13 more sources
A high particle to infectivity ratio is a feature common to many RNA viruses, with ~90-99% of particles unable to initiate a productive infection under low multiplicity conditions. A recent publication by Brooke et al.
Judith M Fonville +4 more
doaj +1 more source

