Results 11 to 20 of about 22,607 (211)

Fitness cost of reassortment in human influenza. [PDF]

PLoS Pathogens, 2017
Reassortment, which is the exchange of genome sequence between viruses co-infecting a host cell, plays an important role in the evolution of segmented viruses.
Mara Villa, Michael Lässig
doaj   +4 more sources

Predicting Hotspots for Influenza Virus Reassortment [PDF]

Emerging Infectious Diseases, 2013
The 1957 and 1968 influenza pandemics, each of which killed ≈1 million persons, arose through reassortment events. Influenza virus in humans and domestic animals could reassort and cause another pandemic.
Trevon L. Fuller, Marius Gilbert, Vincent Martin, Julien Cappelle, Parviez Hosseini, Kevin Y. Njabo, Soad Abdel Aziz, Xiangming Xiao, Peter Daszak, Thomas B. Smith   +9 more
doaj   +4 more sources

New approaches for unravelling reassortment pathways [PDF]

BMC Evolutionary Biology, 2013
Background Every year the human population encounters epidemic outbreaks of influenza, and history reveals recurring pandemics that have had devastating consequences.
Svinti Victoria, Cotton James A, McInerney James O   +2 more
doaj   +3 more sources

TreeKnit: Inferring ancestral reassortment graphs of influenza viruses. [PDF]

PLoS Computational Biology, 2022
When two influenza viruses co-infect the same cell, they can exchange genome segments in a process known as reassortment. Reassortment is an important source of genetic diversity and is known to have been involved in the emergence of most pandemic ...
Pierre Barrat-Charlaix, Timothy G Vaughan, Richard A Neher   +2 more
doaj   +7 more sources

Pathogenesis and Transmission of a Reassorted H1 Influenza A Virus Detected in North American Swine. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background The USDA influenza A virus in swine national surveillance plan identified an increase in the detection frequency of a group of swine 1A.1.1.3 hemagglutinin (HA) clade viruses. This change was associated with reassortment events that resulted in new neuraminidase (NA) gene pairings.
Goulart DB, Souza CK, Zanella GC, Snyder CA, Zanella JC, Markin A, Arruda B, Anderson TK, Baker AL.   +8 more
europepmc   +2 more sources

Development of reassortant influenza vaccines: classical reassortment or reverse genetics?

Russian Journal of Infection and Immunity, 2023
An important feature of influenza vaccines, which distinguishes them from other immunobiological preparations, is that they have no fixed composition. Due to the constant influenza virus antigenic variability, production facilities require timely supply with relevant vaccine strains undoable due to the lack of proper method for the convenient, rapid ...
Irina V. Kiseleva, Larisa G. Rudenko
openaire   +1 more source

Characterizing the Core Internal Gene Pool of H9N2 Responsible for Continuous Reassortment With Other Influenza A Viruses

Frontiers in Microbiology, 2021
Reassortment among avian influenza viruses is the main source of novel avian influenza virus subtypes. Studies have shown that the H9N2 virus often donates internal segments to generate novel reassortant avian influenza viruses, acting as a reassortment ...
Haoyi Yang, Haoyi Yang, Mingda Hu, Boqian Wang, Yuan Jin, Xingfei Gong, Xingfei Gong, Long Liang, Junjie Yue, Wei Chen, Hongguang Ren   +10 more
doaj   +1 more source

Frequency of influenza H3N2 intra-subtype reassortment: attributes and implications of reassortant spread [PDF]

BMC Biology, 2016
De plus en plus de preuves suggèrent que le réassortiment de la grippe contribue non seulement à l'émergence de nouvelles pandémies humaines, mais joue également un rôle important dans les épidémies de grippe saisonnière, la gravité de la maladie, l'évolution et l'efficacité des vaccins.
Irina Maljkovic Berry, Melanie C. Melendrez, Tao Li, Anthony W. Hawksworth, Gary T. Brice, Patrick J. Blair, Eric S. Halsey, Maya Williams, Stefan Fernandez, In‐Kyu Yoon, Leslie Edwards, Robert A. Kuschner, Xiangui Lin, Stephen J. Thomas, Richard G. Jarman   +14 more
openaire   +2 more sources

Reassortment Between Divergent Strains of Camp Ripley Virus (Hantaviridae) in the Northern Short-Tailed Shrew (Blarina brevicauda)

Frontiers in Cellular and Infection Microbiology, 2020
Genomic reassortment of segmented RNA virus strains is an important evolutionary mechanism that can generate novel viruses with profound effects on human and animal health, such as the H1N1 influenza pandemic in 2009 arising from reassortment of two ...
Schuyler W. Liphardt, Hae Ji Kang, Satoru Arai, Se Hun Gu, Joseph A. Cook, Richard Yanagihara   +5 more
doaj   +1 more source

Genome-Wide Reassortment Analysis of Influenza A H7N9 Viruses Circulating in China during 2013–2019

Viruses, 2022
Reassortment with the H9N2 virus gave rise to the zoonotic H7N9 avian influenza virus (AIV), which caused more than five outbreak waves in humans, with high mortality.
Dongchang He, Xiyue Wang, Huiguang Wu, Xiaoquan Wang, Yayao Yan, Yang Li, Tiansong Zhan, Xiaoli Hao, Jiao Hu, Shunlin Hu, Xiaowen Liu, Chan Ding, Shuo Su, Min Gu, Xiufan Liu   +14 more
doaj   +1 more source