New approaches for unravelling reassortment pathways [PDF]
BMC Evolutionary Biology, 2013 Background Every year the human population encounters epidemic outbreaks of influenza, and history reveals recurring pandemics that have had devastating consequences.
Svinti Victoria +2 more
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Predicting Hotspots for Influenza Virus Reassortment [PDF]
Emerging Infectious Diseases, 2013 The 1957 and 1968 influenza pandemics, each of which killed ≈1 million persons, arose through reassortment events. Influenza virus in humans and domestic animals could reassort and cause another pandemic.
Trevon L. Fuller +9 more
doaj +6 more sources
Bayesian inference of reassortment networks reveals fitness benefits of reassortment in human influenza viruses [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Genetic recombination processes, such as reassortment, make it complex or impossible to use standard phylogenetic and phylodynamic methods. This is due to the fact that the shared evolutionary history of individuals has to be represented by a phylogenetic network instead of a tree.
Nicola F. Müller +4 more
openaire +6 more sources
Revealing Reassortment in Influenza A Viruses with TreeSort [PDF]
Molecular Biology and EvolutionAbstract Reassortment among influenza A viruses (IAV) facilitates evolution and has been associated with interspecies transmission and pandemics. We introduce a novel tool called TreeSort that accurately identifies recent and ancestral reassortment events on datasets with thousands of IAV whole genomes.
Koichiro Tamura +2 more
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HopPER: an adaptive model for probability estimation of influenza reassortment through host prediction [PDF]
BMC Medical Genomics, 2020 Background Influenza reassortment, a mechanism where influenza viruses exchange their RNA segments by co-infecting a single cell, has been implicated in several major pandemics since 19th century.
Rui Yin +3 more
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Reassortment Patterns in Swine Influenza Viruses [PDF]
PLoS Currents, 2009 Previous human influenza pandemics were the results of emerging viruses from non-human reservoirs, with at least two caused by strains of mixed human and avian origin. Also, many cases of swine influenza viruses have reportedly infected humans, including the recent human H1N1 strain, isolated in Mexico and the United States.
Hossein Khiabanian +2 more
openaire +7 more sources
Rift Valley Fever Phlebovirus Reassortment Study in Sheep [PDF]
VirusesRift Valley fever (RVF) in ungulates and humans is caused by a mosquito-borne RVF phlebovirus (RVFV). Live attenuated vaccines are used in livestock (sheep and cattle) to control RVF in endemic regions during outbreaks.
Velmurugan Balaraman +14 more
doaj +5 more sources
TreeKnit: Inferring ancestral reassortment graphs of influenza viruses. [PDF]
PLoS Computational Biology, 2022 When two influenza viruses co-infect the same cell, they can exchange genome segments in a process known as reassortment. Reassortment is an important source of genetic diversity and is known to have been involved in the emergence of most pandemic ...
Pierre Barrat-Charlaix +2 more
doaj +2 more sources
Analyses and Insights into Genetic Reassortment and Natural Selection as Key Drivers of Piscine orthoreovirus Evolution [PDF]
VirusesPiscine orthoreovirus (PRV) is a pathogen that causes heart and skeletal muscle inflammation in Salmo salar and has also been linked to circulatory disorders in other farmed salmonids, such as Oncorhynchus kisutch and Oncorhynchus mykiss. The virus has a
Laura Solarte-Murillo +5 more
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Probing orthobunyavirus reassortment using Bunyamwera and Batai viruses as models. [PDF]
PLoS Neglected Tropical DiseasesReassortment is a critical evolutionary mechanism for segmented viruses, enabling the exchange of intact genome segments during co-infection and driving orthobunyavirus evolution; however, the molecular mechanisms underpinning this process remain unclear.
James M Bowen +7 more
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