Results 41 to 50 of about 16,546 (197)

Genetic Evolution of Avian Influenza A (H9N2) Viruses Isolated from Domestic Poultry in Uganda Reveals Evidence of Mammalian Host Adaptation, Increased Virulence and Reduced Sensitivity to Baloxavir

Viruses, 2022
A (H9N2) avian influenza A viruses were first detected in Uganda in 2017 and have since established themselves in live bird markets. The aim of this study was to establish the subsequent genetic evolution of H9N2 viruses in Uganda.
Gladys Atim, Titus Tugume, Qouilazoni A. Ukuli, Bernard Erima, Andrew Mubiru, Hannah Kibuuka, Edison Mworozi, Pamela McKenzie, Jasmine C. M. Turner, David Walker, Trushar Jeevan, Robert G. Webster, Jeremy Jones, Richard J. Webby, Mariette F. Ducatez, Fred Wabwire-Mangen, Denis K. Byarugaba   +16 more
doaj   +1 more source

Terminal reassortment drives the quantum evolution of type III effectors in bacterial pathogens. [PDF]

PLoS Pathogens, 2006
Many bacterial pathogens employ a type III secretion system to deliver type III secreted effectors (T3SEs) into host cells, where they interact directly with host substrates to modulate defense pathways and promote disease.
John Stavrinides, Wenbo Ma, David S Guttman   +2 more
doaj   +1 more source

Evolution of Avian Influenza Virus (H3) with Spillover into Humans, China

Emerging Infectious Diseases, 2023
The continuous evolution of avian influenza viruses (AIVs) of subtype H3 in China and the emergence of human infection with AIV subtype H3N8 highlight their threat to public health.
Jiaying Yang, Ye Zhang, Lei Yang, Xiyan Li, Hong Bo, Jia Liu, Min Tan, Wenfei Zhu, Yuelong Shu, Dayan Wang   +9 more
doaj   +1 more source

Using homologous network to identify reassortment risk in H5Nx avian influenza viruses.

PLoS Computational Biology
The resurgence of H5Nx reassortment has caused multiple epidemics resulting in severe disease even death in wild birds and poultry. Assessing H5Nx reassortment risk is crucial for designing targeted interventions and enhancing preparedness efforts to ...
Ruihao Gong, Zijian Feng, Yanyun Zhang
doaj   +1 more source

Whole-Genome Analyses Identifies Multiple Reassortant Rotavirus Strains in Rwanda Post-Vaccine Introduction

Viruses, 2021
Children in low-and middle-income countries, including Rwanda, experience a greater burden of rotavirus disease relative to developed countries. Evolutionary mechanisms leading to multiple reassortant rotavirus strains have been documented over time ...
Sebotsana Rasebotsa, Jeannine Uwimana, Milton T. Mogotsi, Kebareng Rakau, Nonkululeko B. Magagula, Mapaseka L. Seheri, Jason M. Mwenda, M. Jeffrey Mphahlele, Saheed Sabiu, Richard Mihigo, Leon Mutesa, Martin M. Nyaga   +11 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Complete analysis of the H5 hemagglutinin and N8 neuraminidase phylogenetic trees reveals that the H5N8 subtype has been produced by multiple reassortment events [PDF]

, 2016
The analysis of the complete H5 hemagglutinin and H8 neuraminidase phylogenetic trees presented in this paper shows that the H5N8 avian influenza has been generated by multiple reassortment events.
Dalby, A.R.
core   +1 more source

The effective rate of influenza reassortment is limited during human infection.

PLoS Pathogens, 2017
We characterise the evolutionary dynamics of influenza infection described by viral sequence data collected from two challenge studies conducted in human hosts. Viral sequence data were collected at regular intervals from infected hosts.
Ashley Sobel Leonard, Micah T McClain, Gavin J D Smith, David E Wentworth, Rebecca A Halpin, Xudong Lin, Amy Ransier, Timothy B Stockwell, Suman R Das, Anthony S Gilbert, Rob Lambkin-Williams, Geoffrey S Ginsburg, Christopher W Woods, Katia Koelle, Christopher J R Illingworth   +14 more
doaj   +1 more source

Impacts of the Australian Black Summer Fires on Bat Occupancy and Activity: The Role of Traits and Conservation Status

Animal Conservation, EarlyView.
The response of bats to Australian megafires was assessed one year after fires. High severity fire had a negative effect on total bat activity and the activity or occupancy of six species, while a further 10 species was not associated with any fire covariate. Overall, bat responses were complex and not easily predicted by traits alone.
B. Law, G. Madani, L. Gonsalves, L. Hall, A. Sujaraj, I. Kerr, A. Lloyd, C. Turbill   +7 more
wiley   +1 more source

Individual-specific reassortment rates.

, 2017
A. Optimal reassortment rates inferred for individual subjects. Error bars, shown as horizontal lines, correspond to confidence intervals obtained via a likelihood ratio test. B. Correlation between the extent of evidence for a limited reassortment rate,
Ashley Sobel Leonard (2738740), Christopher W. Woods (104194), Xudong Lin (88866), Amy Ransier (3723697), David E. Wentworth (422363), Micah T. McClain (200348), Suman R. Das (236651), Anthony S. Gilbert (444037), Christopher J. R. Illingworth (108200), Katia Koelle (82611), Gavin J. D. Smith (150548), Rob Lambkin-Williams (444042), Rebecca A. Halpin (177954), Geoffrey S. Ginsburg (104197), Timothy B. Stockwell (249318)   +14 more
core   +1 more source