Results 51 to 60 of about 307,248 (265)

Raymond Lavertue on Dorr and the Anti-Slavery Movement [PDF]

open access: yes, 2012
In this interview, Raymond Lavertue of St. Catherine\u27s College, University of Oxford, discusses Thomas Wilson Dorr\u27s evolving relationship with the anti-slavery movement. To view this video interview please visit the Dorr Rebellion Project web site’
Lavertue, Raymond
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Fiestas, borracheras y rebeliones (Introducción y transcripción del expediente de averiguación del tumulto acaecido en Ingaguasi, 1777)1

open access: yesEstudios Atacameños
Este artículo consta de una introducción y de la transcripción del expediente de la rebelión acontecida en Ingaguasi en 1775 (jurisdicción de la provincia de Atacama).
Nelson Castro F   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Ideology, Grandstanding, and Strategic Party Disloyalty in British Parliament [PDF]

open access: yes, 2017
Strong party discipline is a core feature of Westminster parliamentary systems. Parties typically compel Members of Parliament (MPs) to support the party position regardless of MPs' individual preferences. Rebellion, however, does occur.
Cowley   +7 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

El concepto de lo político: la necesidad de un criterio (inevitablemente transitorio)

open access: yesRevista de Estudios Sociales, 2013
"The Concept of the Political: The Need for a (Inevitably Temporary) Criterion" is an exact title, useful and suggestive. This paper begins with the discussion developed by Carl Schmitt in his book The Concept of the Political (Der Begriff des ...
Daniel Hurtado
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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