Results 51 to 60 of about 103,970 (298)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Adiposity rebound and body mass index in Japanese patients with congenital hypothyroidism

Clinical Pediatric Endocrinology
The long-term prognosis of congenital hypothyroidism (CH) has become apparent since the introduction of newborn screening programs; however, the risk of obesity in patients with CH remains unclear. Early adiposity rebound (AR) is one of the predictors of obesity in adults.
Nakayama, Kanako, Kaneko, Naoya, Hishimura, Nozomi, Yamaguchi, Takeshi, Morikawa, Shuntaro, Yokota, Isao, Kamasaki, Hotaka, Nagasaki, Keisuke, Hasegawa, Yukihiro, Nakamura, Akie   +9 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The conundrum of stock versus bond prices

, 2003
In a general way, stock and bond prices do not display any significant correlation. Yet, if we concentrate our attention on specific episodes marked by a crash followed by a rebound, then we observe that stock prices have a strong connection with ...
Bertrand M Roehner, Macaulay, Maslov, Roehner, Sergei Maslov, Sornette, Vandewalle   +6 more
core   +2 more sources

Adiposity rebound may be a predictive index of body size for adolescents—Based on retrospective cohort data in a Japanese rural area

Obesity Research & Clinical Practice, 2022
We aimed to examine whether the timing of adiposity rebound (AR) could be a predictive index of body size in Japanese adolescents.The longitudinal individual data of 1438 Japanese children, including 714 boys and 724 girls born between 2001 and 2007, were obtained from child health check-ups conducted at ages 1.5, 2, 3, and 5 years, and then yearly ...
Chiyori Haga, Hiroshi Yokomichi, Kyoko Tsuji, Zentaro Yamagata   +3 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study

Frontiers in Endocrinology, 2022
ObjectivesThe objective of this study is to investigate whether body mass index (BMI) changes are associated with fasting glucose and insulin resistance (IR) in early childhood.MethodsFrom the Environment and Development of Children (EDC) cohort, 334 ...
Hye Jin Lee, Youn-Hee Lim, Yun-Chul Hong, Yun-Chul Hong, Yun-Chul Hong, Choong Ho Shin, Young Ah Lee   +6 more
doaj   +1 more source

Separating Algorithms From Questions and Causal Inference With Unmeasured Exposures: An Application to Birth Cohort Studies of Early Body Mass Index Rebound

American Journal of Epidemiology, 2021
Abstract Observational studies reporting on adjusted associations between childhood body mass index (BMI; weight (kg)/height (m)2) rebound and subsequent cardiometabolic outcomes have often not paid explicit attention to causal inference, including definition of a target causal effect and assumptions for unbiased estimation of that ...
Izzuddin M, Aris, Aaron L, Sarvet, Mats J, Stensrud, Romain, Neugebauer, Ling-Jun, Li, Marie-France, Hivert, Emily, Oken, Jessica G, Young   +7 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

UKERC Review of evidence for the rebound effect: Technical report 5: Energy, productivity and economic growth studies [PDF]

, 2007
This report forms part of the TPA’s assessment of evidence for a rebound effect from improved energy efficiency. Technical Report 5 focuses upon the relationship between energy, productivity and economic growth and examines the claim that improved energy
Dimitropoulos, John, Sorrell, Steve
core   +1 more source