Results 61 to 70 of about 2,128 (154)
Generation of a Biomimetic Substitute of the Corneal Limbus Using Decellularized Scaffolds
Pharmaceutics, 2021 Patients with severe limbal damage and limbal stem cell deficiency are a therapeutic challenge. We evaluated four decellularization protocols applied to the full-thickness and half-thickness porcine limbus, and we used two cell types to recellularize the
David Sánchez-Porras +7 more
doaj +1 more source
The Recellularized Liver Matrix: A Novel Way of Transplantation? [PDF]
Hepatology, 2010 Abstract Orthotopic liver transplantation is the only available treatment for severe liver failure, but it is currently limited by organ shortage.
Christer, Baeck, Konrad, Streetz
openaire +2 more sources
Organ Transplantation: Current Status, Challenges, and Future Prospects
MedComm, Volume 7, Issue 1, January 2026.Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Xinqiang Li, Ruidong Ding, Jinzhen Cai
wiley +1 more source
Preparation of Decellularized Liver Scaffolds and Recellularized Liver Grafts [PDF]
, 2017 Severe liver disease is the 12th leading cause of death in the USA, with organ transplantation often being the only viable option for treatment. However, due to the shortage of viable donor livers, it is estimated that over 1200 patients died in 2015 while waiting for liver transplantation.
Yibin, Chen +3 more
openaire +2 more sources
JGH Open, Volume 9, Issue 12, December 2025.ABSTRACT The gastrointestinal (GI) tract plays a vital role in regulating metabolic pathways, nutrient absorption, and cellular homeostasis. Abnormalities in the GI tract often arise from unhealthy lifestyles, genetic mutations, and prolonged medication use, leading to disorders such as ulcers, cirrhosis, and malignancies.
Archna Dhasmana +6 more
wiley +1 more source
Bioengineering, 2023 Acute Liver Failure (ALF) is a life-threatening illness characterized by the rapid onset of abnormal liver biochemistries, coagulopathy, and the development of hepatic encephalopathy.
Victoria L. Nelson +10 more
doaj +1 more source
Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions
MedComm, Volume 6, Issue 12, December 2025.A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu +4 more
wiley +1 more source
Regenerative TherapyObjectives: Tissue engineering approaches via repopulation of acellular biological grafts provide an exciting opportunity to generate lung grafts for transplantation. Alveolar type 2 (AT2) cells are a promising cell source for re-epithelialization. There
Daisuke Taniguchi +7 more
doaj +1 more source
Human-Origin iPSC-Based Recellularization of Decellularized Whole Rat Livers
Bioengineering, 2022 End-stage liver diseases lead to mortality of millions of patients, as the only treatment available is liver transplantation and donor scarcity means that patients have to wait long periods before receiving a new liver.
Aylin Acun +4 more
doaj +1 more source
VIEW, Volume 6, Issue 6, December 2025.Angiogenesis is an essential process in tissue regeneration, as it prevents complications such as necrosis, inflammation, and fibrosis. mADM decellularized by the supercritical carbon dioxide method exhibits high preservation of the extracellular matrix and various growth factors.
Hyo‐Jin Kim +14 more
wiley +1 more source