Results 71 to 80 of about 2,128 (154)

Revolutionizing Heart Valve Therapy: A Translational Framework for Combining Decellularized Scaffolds With Genetic Modification

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 11, November 2025.
ABSTRACT Valvular heart disease (VHD) represents a significant global health challenge, affecting over 2.5% of the population and disproportionately impacting older adults due to age‐related degenerative processes. Current treatment options—mechanical and bioprosthetic valves—both present substantial limitations that impact patient quality of life and ...
Nikolaos P. Tzavellas, Natalia Atzemoglou, Efstathios L. Pavlidis, Alkinoos Nikolis, Georgios S. Markopoulos, Konstantinos I. Tsamis, Dimitrios Peschos, Yannis V. Simos, Lampros Lakkas   +8 more
wiley   +1 more source

Biomimetic Cell Membrane‐Coated Scaffolds for Enhanced Tissue Regeneration

Advanced Materials, Volume 37, Issue 40, October 9, 2025.
This review examines the development and use of cell membrane‐coated scaffolds in tissue engineering. Bioinspired phospholipid and glycocalyx coatings enhance anti‐fouling, anti‐thrombogenic, and selective molecular recognition properties. Native cell membrane coatings further support cell‐specific interactions, immune modulation, and reduced bacterial
Carmen Alvarez‐Lorenzo, Alejandro Ramirez‐Romero, Diana Peixoto, Maria Vivero‐Lopez, Isabel Rodríguez‐Moldes, Angel Concheiro   +5 more
wiley   +1 more source

In Vitro Assessment and Preliminary In Vivo Characterization of Innovative Hybrid Materials for Biomedical Applications

Journal of Biomedical Materials Research Part A, Volume 113, Issue 10, October 2025.
ABSTRACT Hybrid materials are gaining increasing attention for several applications since they properly combine biological and synthetic components, leveraging the advantages of both; thus, these materials can integrate with the host organism to support proper functions, offering new promising solutions, especially in the biomedical field.
Martina Todesco, Roberto Luisetto, Martina Casarin, Edi Simoni, Diego Penzo, Deborah Sandrin, Michele Modesti, Laura Astolfi, Giovanna Albertin, Filippo Romanato, Massimo Marchesan, Gino Gerosa, Chiara Giulia Fontanella, Andrea Bagno   +13 more
wiley   +1 more source

Dynamic Loading Does Not Interfere With the Initial Repopulation of Decellularized Tendons: An Ex Vivo Study

Journal of Biomedical Materials Research Part A, Volume 113, Issue 10, October 2025.
ABSTRACT Rupture of the anterior cruciate ligament (ACL) is a common injury resulting in joint instability. Tendon autografts, the gold standard to reconstruct a ruptured ACL, contain dead or dying cells upon implantation that can initiate early localized catabolic and inflammatory events.
Janne Spierings, Florencia Abinzano, Elias Salzer, Jurgen Bulsink, Rob Janssen, Keita Ito, Jasper Foolen   +6 more
wiley   +1 more source

A Tissue Engineering's Guide to Biomimicry

Macromolecular Bioscience, Volume 25, Issue 10, October 2025.
This review categorizes biomimicry in tissue engineering into mechanical, morphological, and biological strategies. It explores how each aspect contributes to replicating native tissue function and structure, highlighting current techniques and emerging approaches.
Kenny A. van Kampen, Carlos Mota, Lorenzo Moroni   +2 more
wiley   +1 more source

Structural basis of interaction between mesenchymal stem cells and decellularized rat heart matrix

Кубанский научный медицинский вестник, 2015
The study presents data about structural interaction between decellularizedrat heart matrix and stem cells used for recellularization. The effect of decellularized scaffold influence on the potential cells ability for differentiation without growth ...
A. S. Sotnichenko, A. A. Slavinsky, I. V. Gilevich, E. V. Kuevda, I. S. Gumenyuk, E. A. Gubareva, P. . Macchiarini   +6 more
doaj  

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, Volume 14, Issue 20, August 8, 2025.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction

Advanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.
This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi, Beatrice Auletta, Luigi Sartore, Marco La Placa, Giada Cecconi, Pietro Chiolerio, Edoardo Maghin, Silvia Angiolillo, Eugenia Carraro, Onelia Gagliano, Cecilia Laterza, Nicola Elvassore, Martina Piccoli, Anna Urciuolo   +13 more
wiley   +1 more source

A novel agarose-free, standardized generation and versatile ECM characterization of decellularized scaffolds from normal and fibrotic human lung tissue

Frontiers in Bioengineering and Biotechnology
BackgroundThe extracellular matrix (ECM) is a key regulator of tissue homeostasis and remodeling in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (FHP).
Eike B. Preuß, Eike B. Preuß, Lara-Jasmin Schröder, Lara-Jasmin Schröder, Charlotte Hähner, Jérôme A. von Bandemer, Christopher Werlein, Edith K. J. Schwarz, Edith K. J. Schwarz, Stephanie Schubert, Holger Schlüter, Matthew J. Thomas, Danny D. Jonigk, Danny D. Jonigk, Jan C. Kamp, Jan C. Kamp, Mark P. Kühnel, Mark P. Kühnel   +17 more
doaj   +1 more source

Decellularisation of human meniscus tissue using sodium dodecyl sulphate (SDS): Preserving biomechanical integrity for scaffold‐based meniscal repair

Journal of Experimental Orthopaedics, Volume 12, Issue 3, July 2025.
Abstract Purpose Meniscal tears are common knee injuries and a major risk factor for secondary osteoarthritis. Recently, there has been a paradigm shift toward meniscal preservation, reflecting the meniscus's vital role. In this context, tissue engineering approaches such as the development of meniscal scaffolds have gained attention.
Dominic Simon, Benjamin Bartz, Manuel Kistler, Susanne Mayer‐Wagner, Peter E. Müller, Thomas R. Niethammer, Boris M. Holzapfel, Gautier Beckers   +7 more
wiley   +1 more source