Results 71 to 80 of about 4,532 (195)

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source

Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization [PDF]

, 2017
The development of human liver scaffolds retaining their 3-dimensional structure and extra-cellular matrix (ECM) composition is essential for the advancement of liver tissue engineering.
A Bader, A Dash, A Vivares, AJ Engler, BD Elder, BE Uygun, C Trautwein, CM Nelson, D Mavri-Damelin, D Schuppan, D Sokocevic, DE Discher, DK Mishra, E Meezan, FJ Rodriguez, G Mazza, G Mazza, G Orlando, G Steinhoff, G Totonelli, I Mederacke, I Notingher, J Folkman, JJ Song, JM Fishman, JP Guyette, K Rombouts, K Schenke-Layland, M Monici, M Piccoli, M Pinzani, P Bornstein, P Gissen, P Lin, P Maghsoudlou, PM Crapo, R Ahmadi, RG Wells, S Baiguera, S Marastoni, SE Gilpin, SK Goh, SL Dahl, TD Schmittgen, TT Nguyen, Y Wang   +45 more
core   +6 more sources

Human skin‐derived micronized acellular dermal matrix modulates angiogenesis to enhance tissue reconstruction

VIEW, Volume 6, Issue 6, December 2025.
Angiogenesis is an essential process in tissue regeneration, as it prevents complications such as necrosis, inflammation, and fibrosis. mADM decellularized by the supercritical carbon dioxide method exhibits high preservation of the extracellular matrix and various growth factors.
Hyo‐Jin Kim, Won‐Hong Min, Soohyun Kim, Duri Lee, Jin Woo Bae, Yongwoo Shin, Kyusup An, Bo‐Gyeong Seo, Won‐bin Jo, Kwang Dong Kim, Jiyun Yoo, Hyuk‐Kwon Kwon, Jeong‐Hyung Lee, Ki Yong Hong, Cheol Hwangbo   +14 more
wiley   +1 more source

Revolutionizing Heart Valve Therapy: A Translational Framework for Combining Decellularized Scaffolds With Genetic Modification

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 11, November 2025.
ABSTRACT Valvular heart disease (VHD) represents a significant global health challenge, affecting over 2.5% of the population and disproportionately impacting older adults due to age‐related degenerative processes. Current treatment options—mechanical and bioprosthetic valves—both present substantial limitations that impact patient quality of life and ...
Nikolaos P. Tzavellas, Natalia Atzemoglou, Efstathios L. Pavlidis, Alkinoos Nikolis, Georgios S. Markopoulos, Konstantinos I. Tsamis, Dimitrios Peschos, Yannis V. Simos, Lampros Lakkas   +8 more
wiley   +1 more source

Innovative Biotechnology for Generation of Cardiac Tissue

Applied Sciences, 2021
Heart transplantation remains the only curative treatment for end-stage heart failure. This life-saving option continues to be limited by the low number of organ donors, graft rejection and adverse effects of immunosuppressants. Engineering bioartificial
Greta Ionela Barbulescu, Florina Maria Bojin, Valentin Laurentiu Ordodi, Iacob Daniel Goje, Taddeus Paul Buica, Oana Isabella Gavriliuc, Flavia Baderca, Teodora Hoinoiu, Virgil Paunescu   +8 more
doaj   +1 more source

Biomimetic Cell Membrane‐Coated Scaffolds for Enhanced Tissue Regeneration

Advanced Materials, Volume 37, Issue 40, October 9, 2025.
This review examines the development and use of cell membrane‐coated scaffolds in tissue engineering. Bioinspired phospholipid and glycocalyx coatings enhance anti‐fouling, anti‐thrombogenic, and selective molecular recognition properties. Native cell membrane coatings further support cell‐specific interactions, immune modulation, and reduced bacterial
Carmen Alvarez‐Lorenzo, Alejandro Ramirez‐Romero, Diana Peixoto, Maria Vivero‐Lopez, Isabel Rodríguez‐Moldes, Angel Concheiro   +5 more
wiley   +1 more source

Investigating neovascularization in rat decellularized intestine - an in vitro platform for studying angiogenesis [PDF]

, 2016
One of the main challenges currently faced by tissue engineers is the loss of tissues post implantation due to delayed neovascularization. Several strategies are under investigation to create vascularized tissue but none have yet overcome this problem.
Chong, C., Dew, L., English, W., MacNeil, S.   +3 more
core   +1 more source

In Vitro Assessment and Preliminary In Vivo Characterization of Innovative Hybrid Materials for Biomedical Applications

Journal of Biomedical Materials Research Part A, Volume 113, Issue 10, October 2025.
ABSTRACT Hybrid materials are gaining increasing attention for several applications since they properly combine biological and synthetic components, leveraging the advantages of both; thus, these materials can integrate with the host organism to support proper functions, offering new promising solutions, especially in the biomedical field.
Martina Todesco, Roberto Luisetto, Martina Casarin, Edi Simoni, Diego Penzo, Deborah Sandrin, Michele Modesti, Laura Astolfi, Giovanna Albertin, Filippo Romanato, Massimo Marchesan, Gino Gerosa, Chiara Giulia Fontanella, Andrea Bagno   +13 more
wiley   +1 more source

Generation of a Biomimetic Substitute of the Corneal Limbus Using Decellularized Scaffolds

Pharmaceutics, 2021
Patients with severe limbal damage and limbal stem cell deficiency are a therapeutic challenge. We evaluated four decellularization protocols applied to the full-thickness and half-thickness porcine limbus, and we used two cell types to recellularize the
David Sánchez-Porras, Manuel Caro-Magdaleno, Carmen González-Gallardo, Óscar Darío García-García, Ingrid Garzón, Víctor Carriel, Fernando Campos, Miguel Alaminos   +7 more
doaj   +1 more source

A comparison of three methods of decellularization of pig corneas to reduce immunogenicity. [PDF]

, 2014
AIM: To investigate whether decellularization using different techniques can reduce immunogenicity of the cornea, and to explore the decellularized cornea as a scaffold for cultured corneal endothelial cells (CECs).
Cooper, David KC, Hara, Hidetaka, Lee, Whayoung, Long, Cassandra, Miyagawa, Yuko   +4 more
core   +1 more source