Results 61 to 70 of about 2,229 (161)

A proposed model of xeno-keratoplasty using 3D printing and decellularization

Frontiers in Pharmacology, 2023
Corneal opacity is a leading cause of vision impairment and suffering worldwide. Transplantation can effectively restore vision and reduce chronic discomfort. However, there is a considerable shortage of viable corneal graft tissues.
Xinyu Wang, Xinyu Wang, Rawdah Taha Elbahrawi, Azhar Mohamud Abdukadir, Zehara Mohammed Ali, Vincent Chan, Peter R. Corridon, Peter R. Corridon, Peter R. Corridon, Peter R. Corridon   +9 more
doaj   +1 more source

Design Principles and Mechanics: A Review of Emerging Paradigms in Intervertebral Disc Regeneration and Replacement

Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.
Low back pain, a major global cause of disability, arises primarily from intervertebral disc (IVD) degeneration and imposes significant socioeconomic impacts, especially in aging and obese populations. Current treatments, fusion and total disc replacement, fail to fully replicate native disc biomechanics.
Vinayak Vijayan, Lihua Lou
wiley   +1 more source

Tissue Engineering of Recellularized Small-Diameter Vascular Grafts [PDF]

Tissue Engineering, 2005
A tissue-engineered small-diameter arterial graft would be of benefit to patients requiring vascular reconstructive procedures. Our objective was to produce a tissue-engineered vascular graft with a high patency rate that could withstand arterial pressures.
Borschel, Gregory H., Huang, Yen-Chih, Calve, Sarah, Arruda, Ellen M., Lynch, Jennifer B., Dow, Douglas E., Kuzon, William M., Dennis, Robert G., Brown, David L.   +8 more
openaire   +3 more sources

Organ Transplantation: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Xinqiang Li, Ruidong Ding, Jinzhen Cai
wiley   +1 more source

Tissue specificity of decellularized rhesus monkey kidney and lung scaffolds. [PDF]

PLoS ONE, 2013
Initial steps in establishing an optimal strategy for functional bioengineered tissues is generation of three-dimensional constructs containing cells with the appropriate organization and phenotype.
Karina H Nakayama, C Chang I Lee, Cynthia A Batchelder, Alice F Tarantal   +3 more
doaj   +1 more source

Generation of a Biomimetic Substitute of the Corneal Limbus Using Decellularized Scaffolds

Pharmaceutics, 2021
Patients with severe limbal damage and limbal stem cell deficiency are a therapeutic challenge. We evaluated four decellularization protocols applied to the full-thickness and half-thickness porcine limbus, and we used two cell types to recellularize the
David Sánchez-Porras, Manuel Caro-Magdaleno, Carmen González-Gallardo, Óscar Darío García-García, Ingrid Garzón, Víctor Carriel, Fernando Campos, Miguel Alaminos   +7 more
doaj   +1 more source

Next‐Generation Therapies for Gastrointestinal Repair: Converging Traditional Medicine and Tissue Engineering

JGH Open, Volume 9, Issue 12, December 2025.
ABSTRACT The gastrointestinal (GI) tract plays a vital role in regulating metabolic pathways, nutrient absorption, and cellular homeostasis. Abnormalities in the GI tract often arise from unhealthy lifestyles, genetic mutations, and prolonged medication use, leading to disorders such as ulcers, cirrhosis, and malignancies.
Archna Dhasmana, Indra Rautela, Atul Singh, Ayushi Santhanam, Sumira Malik, R. K. Govindarajan, Subham Preetam   +6 more
wiley   +1 more source

Mesenchymal cells support the early retention of primary alveolar type 2 cells on acellular mouse lung scaffolds

Regenerative Therapy
Objectives: Tissue engineering approaches via repopulation of acellular biological grafts provide an exciting opportunity to generate lung grafts for transplantation. Alveolar type 2 (AT2) cells are a promising cell source for re-epithelialization. There
Daisuke Taniguchi, Mohammadali Ahmadipour, Anthony L. Eiliazadeh, Pascal Duchesneau, Takeshi Nagayasu, Siba Haykal, Golnaz Karoubi, Thomas K. Waddell   +7 more
doaj   +1 more source

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source

Heterotopic transplantation of a decellularized and recellularized whole porcine heart [PDF]

Interactive CardioVascular and Thoracic Surgery, 2016
One of the final treatments for end-stage heart failure is heart transplantation. However, a shortage of donor hearts has created a long waiting list and limited benefits. Our ultimate goal is to create a whole beating heart fabricated on an organ scaffold for human heart transplantation.
Hiroto, Kitahara, Hiroshi, Yagi, Kazuki, Tajima, Kazuma, Okamoto, Akihiro, Yoshitake, Ryo, Aeba, Mikihiko, Kudo, Ichiro, Kashima, Shinji, Kawaguchi, Akinori, Hirano, Mio, Kasai, Yuta, Akamatsu, Hidetoshi, Oka, Yuko, Kitagawa, Hideyuki, Shimizu   +14 more
openaire   +2 more sources