Results 1 to 10 of about 1,346 (172)

Cell therapy in vascularized composite allotransplantation

Biomedical Journal, 2022
Allograft rejection is one of the obstacles in achieving a successful vascularized composite allotransplantation (VCA). Treatments of graft rejection with lifelong immunosuppression (IS) subject the recipients to a lifelong risk of cancer development and
Madonna Rica Anggelia, Hui-Yun Cheng, Ping-Chin Lai, Yun-Huan Hsieh, Chih-Hung Lin, Cheng-Hung Lin   +5 more
doaj   +5 more sources

Unraveling the Roles of Macrophages in Vascularized Composite Allotransplantation [PDF]

Biomedicines
The phenotypic heterogeneity and functional diversity of macrophages have been increasingly appreciated, particularly regarding their roles as innate immune cells in shaping transplantation outcomes.
Hui-Yun Cheng, Madonna Rica Anggelia, Cheng-Hung Lin   +2 more
doaj   +4 more sources

Perfusion decellularization for vascularized composite allotransplantation

SAGE Open Medicine, 2022
Vascularized composite allotransplantation is becoming the emerging standard for reconstructive surgery treatment for patients with limb trauma and facial injuries involving soft tissue loss.
Danielle L Nicholls, Sara Rostami, Golnaz Karoubi, Siba Haykal   +3 more
doaj   +4 more sources

A Guide to the Implementation and Design of Ex Vivo Perfusion Machines for Vascularized Composite Allotransplantation [PDF]

Plastic and Reconstructive Surgery, Global Open
Background:. Ex vivo machine perfusion (EVMP) is a versatile platform utilized in vascularized composite allotransplantation (VCA) to prolong preservation, salvage tissue, and evaluate graft viability. However, there is no consensus on best practices for
Tessa E. Muss, MD, Amanda H. Loftin, DVM, Zachary H. Zamore, BA, Eleni M. Drivas, MD, Yi-Nan Guo, MD, Yichuan Zhang, MS, John Brassil, MS, Byoung Chol Oh, DVM, PhD, Gerald Brandacher, MD, FAST   +8 more
doaj   +3 more sources

Where Do We Stand for Nerve Regeneration and Functional Recovery After Vascularized Composite Allotransplantation? [PDF]

Microsurgery
ABSTRACT Introduction Vascularized composite allotransplantation (VCA) offers a reconstructive solution for patients with severe limb and facial defects by transplanting multiple tissue types—including skin, muscle, bone, and nerves—as a single unit.
Mathieu O, Knoedler L, Schaschinger T, Fenske J, Klimitz FJ, Jeljeli M, Cetrulo CL, Lellouch AG.   +7 more
europepmc   +2 more sources

Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation

SAGE Open Medicine, 2021
Vascularized composite allotransplantation represents the final level of the reconstructive ladder, offering treatment options for severe tissue loss and functional deficiencies.
Shaishav Datta, Aisling M Fitzpatrick, Siba Haykal   +2 more
doaj   +2 more sources

Evolution of the rat hind limb transplant as an experimental model of vascularized composite allotransplantation: Approaches and advantages

SAGE Open Medicine, 2020
As clinical experience with surgical techniques and immunosuppression in vascularized composite allotransplantation recipients has accumulated, vascularized composite allotransplantation for hand and face have become standard of care in some countries ...
Yoram Y Fleissig, Jason E Beare, Amanda J LeBlanc, Christina L Kaufman   +3 more
doaj   +2 more sources

Vascularized composite tissue allotransplantation – state of the art [PDF]

Clinical Transplantation, 2013
AbstractVascularized composite tissue allotransplantation is a viable treatment option for injuries and defects that involve multiple layers of functional tissue. In the past 15 yr, more than 150 vascularized composite allotransplantation (VCA) surgeries have been reported for various anatomic locations including – but not limited to – trachea, larynx,
J Rodrigo Diaz-Siso, Ericka M Bueno, Geoffroy C Sisk   +2 more
exaly   +3 more sources

Evolving ethics, policy and reimbursement issues of vascularized composite allotransplantation: Symposium summary

SAGE Open Medicine, 2019
In this article, we present a report from a national meeting titled, “Evolving Issues of Vascularized Composite Allotransplantation—A Symposium on Ethics, Policy, and Reimbursement Issues,” which convened in September 2017.
John Rose, Carisa M Cooney, Christina Kaufman, Simon G Talbot, Arthur Caplan, Jeffrey Kahn, Jeremy Sugarman, Jaimie T Shores, L Scott Levin, Gerald Brandacher, Sue V McDiarmid, WP Andrew Lee, Wendy Dean   +12 more
doaj   +2 more sources

Immunogenicity and tolerance induction in vascularized composite allotransplantation. [PDF]

Front Transplant
Vascularized composite allotransplantation (VCA) is the transplantation of multiple tissues such as skin, muscle, bone, nerve, and vessels, as a functional unit (i.e., hand or face) to patients suffering from major tissue trauma and functional deficits. Though the surgical feasibility has been optimized, issues regarding graft rejection remains.
Sun JA, Adil A, Biniazan F, Haykal S.
europepmc   +4 more sources