Results 31 to 40 of about 1,741 (203)

Modified mRNA-Based Vaccines Against Coronavirus Disease 2019

Cell Transplantation, 2022
The pandemic of coronavirus disease 2019 (COVID-19) continuously causes deaths worldwide, representing a considerable challenge to health care and economic systems with a new precedent in human history.
Aline Yen Ling Wang
doaj   +1 more source

IL-10 modified mRNA monotherapy prolongs survival after composite facial allografting through the induction of mixed chimerism

Molecular Therapy: Nucleic Acids, 2023
Vascularized composite allotransplantation has great potential in face transplantation by supporting functional restoration following tissue grafting.
Ana Elena Aviña, Dante De Paz, Shu-Chun Huang, Kuan-Hung Chen, Yun-Ching Chang, Chin-Ming Lee, Chia-Hsien Lin, Fu-Chan Wei, Aline Yen Ling Wang   +8 more
doaj   +1 more source

QS9: Decellularization Of Vascularized Composite Allografts In The Rat

Plastic and Reconstructive Surgery, Global Open, 2021
Purpose: The decellularization of Vascularized Composite Allotransplantation (VCA) represents a first step in circumventing the need for immunosuppression by depleting donor cells from VCAs.
ELISE LUPON, M.D, Aylin Acun, PhD, Marion Goutard, M..D, Alexandre G. Lellouch, M.D, MSc, Ruben Oganesyan, M.D, Alec R. Andrews, BS, Laurent Lantieri, M.D, Mark A. Randolph, PhD, Curtis L. Cetrulo, Jr., M.D, FACS, FAAP, Basak Uygun, PhD   +9 more
doaj   +1 more source

Vascularized Composite Allotransplantation: Medical Complications [PDF]

Current Transplantation Reports, 2016
The objective of this review is to summarize the collective knowledge regarding the risks and complications in vascularized composite tissue allotransplantation (VCA), focusing on upper extremity and facial transplantation. The field of VCA has entered its second decade with an increasing experience in both the impressive good outcomes, as well as ...
Uluer, Mehmet C., Brazio, Philip S., Woodall, Jhade D., Nam, Arthur J., Bartlett, Stephen T., Barth, Rolf N.   +5 more
openaire   +2 more sources

Type-I Interferons Inhibit Interleukin-10 Signaling and Favor Type 1 Diabetes Development in Nonobese Diabetic Mice

Frontiers in Immunology, 2018
Destruction of insulin-producing β-cells by autoreactive T lymphocytes leads to the development of type 1 diabetes. Type-I interferons (TI-IFN) and interleukin-10 (IL-10) have been connected with the pathophysiology of this disease; however, their ...
Marcos Iglesias, Anirudh Arun, Maria Chicco, Brandon Lam, C. Conover Talbot, Vera Ivanova, W. P. A. Lee, Gerald Brandacher, Giorgio Raimondi   +8 more
doaj   +1 more source

Tacrolimus-loaded Drug Delivery Systems in Vascularized Composite Allotransplantation: Lessons and Opportunities for Local Immunosuppression. [PDF]

Transplantation
Long-term systemic immunosuppression is needed for vascularized composite allotransplantation (VCA). The high rate of acute rejection episodes in the first posttransplant year, the development of chronic rejection, and the adverse effects that come along
Ben Brahim B, Arenas Hoyos I, Zhang L, Vögelin E, Olariu R, Rieben R.   +5 more
europepmc   +3 more sources

Novel targeted drug delivery systems to minimize systemic immunosuppression in vascularized composite allotransplantation. [PDF]

, 2018
PURPOSE OF REVIEW The long-term adverse effects of immunosuppressive treatment, the high rate of acute rejection and the development of chronic rejection are the main factors preventing a wider clinical application of vascularized composite ...
Taddeo, Adriano, Tsai, Catherine, Vögelin, Esther, Rieben, Robert   +3 more
core   +1 more source

Gluconate-Lactobionate-Dextran Perfusion Solutions Attenuate Ischemic Injury and Improve Function in a Murine Cardiac Transplant Model

Cells, 2022
Static cold storage is the cheapest and easiest method and current gold standard to store and preserve donor organs. This study aimed to compare the preservative capacity of gluconate-lactobionate-dextran (Unisol) solutions to histidine-tryptophan ...
Yinan Guo, Franka Messner, Sarah E. Beck, Marcos Iglesias Lozano, Hubert Schwelberger, Yichuan Zhang, Kai Kammers, Byoung Chol Oh, Elizabeth D. Greene, Gerald Brandacher, Kelvin G. M. Brockbank   +10 more
doaj   +1 more source

Enhancing Immunomodulatory Function of Mesenchymal Stromal Cells by Hydrogel Encapsulation

Cells
Mesenchymal stromal cells (MSCs) showcase remarkable immunoregulatory capabilities in vitro, positioning them as promising candidates for cellular therapeutics. However, the process of administering MSCs and the dynamic in vivo environment may impact the
Hui-Yun Cheng, Madonna Rica Anggelia, Shiao-Chin Liu, Chih-Fan Lin, Cheng-Hung Lin   +4 more
doaj   +1 more source

Patient definitions of transplant success in upper extremity vascularized composite allotransplantation: A mixed-methods study

SAGE Open Medicine, 2023
Objective: Upper extremity vascularized composite allotransplantation is an innovative treatment option for people with upper extremity amputations. Limited patient-relevant long-term outcomes data about transplant success may impede patients’ informed ...
Max C Downey, Jessica Gacki-Smith, Brianna Kuramitsu, Karen B Vanterpool, Michelle Nordstrom, Michelle Luken, Whitney Langlee, Tiffany Riggleman, Shannon Fichter, Withney Altema, Sally E Jensen, Gregory A Dumanian, Carisa M Cooney, Macey L Levan, Scott Tintle, Gerald Brandacher, Elisa J Gordon   +16 more
doaj   +1 more source