Results 51 to 60 of about 1,741 (203)

VCA supercooling in a swine partial hindlimb model

Scientific Reports
Vascularized composite allotransplantations are complex procedures with substantial functional impact on patients. Extended preservation of VCAs is of major importance in advancing this field.
Yanis Berkane, Irina Filz von Reiterdank, Pierre Tawa, Laura Charlès, Marion Goutard, Antonia T. Dinicu, Mehmet Toner, Nicolas Bertheuil, Aebele B. Mink van der Molen, J. Henk Coert, Alexandre G. Lellouch, Mark A. Randolph, Curtis L. Cetrulo, Korkut Uygun   +13 more
doaj   +1 more source

Tolerance of a Vascularized Composite Allograft Achieved in MHC Class-I-mismatch Swine via Mixed Chimerism

Frontiers in Immunology, 2022
BackgroundVascularized composite allografts (VCAs) allow reconstruction of devastating injuries and amputations, yet require lifelong immunosuppression that is associated with significant morbidity.
Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alec R. Andrews, Alec R. Andrews, Alec R. Andrews, Gaelle Saviane, Gaelle Saviane, Gaelle Saviane, Zhi Yang Ng, Zhi Yang Ng, Ilse M. Schol, Ilse M. Schol, Marion Goutard, Marion Goutard, Marion Goutard, Marion Goutard, Amon-Ra Gama, Ivy A. Rosales, Robert B. Colvin, Laurent A. Lantieri, Mark A. Randolph, Mark A. Randolph, Mark A. Randolph, Gilles Benichou, Curtis L. Cetrulo, Curtis L. Cetrulo, Curtis L. Cetrulo, Curtis L. Cetrulo   +29 more
doaj   +1 more source

Recellularization of Bioengineered Scaffolds for Vascular Composite Allotransplantation

Frontiers in Surgery, 2022
Traumatic injuries or cancer resection resulting in large volumetric soft tissue loss requires surgical reconstruction. Vascular composite allotransplantation (VCA) is an emerging reconstructive option that transfers multiple, complex tissues as a whole subunit from donor to recipient.
Aisha Adil, Aisha Adil, Michael Xu, Michael Xu, Michael Xu, Siba Haykal, Siba Haykal, Siba Haykal   +7 more
openaire   +3 more sources

Hand disease in scleroderma: a clinical correlate for chronic hand transplant rejection [PDF]

, 2013
Chronic rejection remains a potential long-term consequence of hand composite tissue allotransplantation (CTA). Scleroderma has already been proposed as a model for chronic facial allograft rejection based on potential parallels of observed progression ...
Puri, A, Butler, PE, Clarke, A, Amin, K; id_orcid, Amin, K, Sivakumar, B, Denton, C   +6 more
core   +1 more source

Exploring Iodide and Hydrogen Sulfide as ROS Scavengers to Delay Acute Rejection in MHC-Defined Vascularized Composite Allografts

Antioxidants
Vascularized composite allografts (VCA) face ischemic challenges due to their limited availability. Reperfusion following ischemia triggers oxidative stress and immune reactions, and scavenger molecules could mitigate ischemia–reperfusion injuries and ...
Philipp Tratnig-Frankl, Alec R. Andrews, Yanis Berkane, Claire Guinier, Marion Goutard, Elise Lupon, Hyshem H. Lancia, Michael L. Morrison, Mark B. Roth, Mark A. Randolph, Curtis L. Cetrulo, Alexandre G. Lellouch   +11 more
doaj   +1 more source

Local injections of tacrolimus-loaded hydrogel reduce systemic immunosuppression-related toxicity in vascularized composite allotransplantation. [PDF]

, 2018
BACKGROUND Routine application of vascularized composite allotransplantation (VCA) is hampered by immunosuppression-related health comorbidities. To mitigate these we developed an inflammation-responsive hydrogel for local immunosuppression.
Olariu, Radu, Leckenby, Jonathan Ian, Esther Voegelin, Jonathan Leckenby, Banz Wälti, Yara, Adriano Taddeo, Dzhuliya V. Dzhonova, Robert Rieben, Rieben, Robert, Ashish Dhayani, Dhayani, Ashish, Praveen K. Vemula, Prost, Jean-Christophe, Dzhonova, Dzhuliya Vihrenova, Jean-Christophe Prost, Radu Olariu, Taddeo, Adriano, Vemula, Praveen K, Vögelin, Esther, Yara Banz   +19 more
core   +1 more source

Case Report: Post-transplant lymphoproliferative disorder as a serious complication of vascularized composite allotransplantation. [PDF]

Front Transplant
Vascularized composite allotransplantation (VCA) is an emerging field in transplant surgery. Despite overall positive outcomes, VCA confers risk for multiple complications related to the procedure and subsequent immunosuppression.
Zaccardelli A, Lucas FM, LaCasce AS, Chandraker AK, Azzi JR, Talbot SG.   +5 more
europepmc   +2 more sources

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, Volume 13, Issue 28, 18 May 2026.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Laryngeal Transplantation in Cancer Patients: Evaluation of Surgical Outcomes and Functional Recovery

MedComm, Volume 7, Issue 5, May 2026.
Our pilot clinical study in laryngeal transplantation achieved divergent outcomes: two cases maintained functional speech/swallowing with around 2 year graft survival and have been ongoing, while two succumbed to sepsis (10mo) and hemorrhagic recurrence (11mo).
Zheng Jiang, Mailudan Ainiwaer, Pengwei Zhao, Yansheng Hu, Xin Yang, Yu Xiong, Bin Zeng, Longhao Wang, Jun Liu, Fei Chen   +9 more
wiley   +1 more source