Results 41 to 50 of about 1,741 (203)

Toward transplantation tolerance with adipose tissue-derived therapeutics

Frontiers in Immunology, 2023
Solid organ and composite tissue allotransplanation have been widely applied to treat end-stage organ failure and massive tissue defects, respectively. Currently there are a lot of research endeavors focusing on induction of transplantation tolerance, to
Hui-Yun Cheng, Madonna Rica Anggelia, Cheng-Hung Lin, Cheng-Hung Lin, Cheng-Hung Lin, Fu-Chan Wei, Fu-Chan Wei, Fu-Chan Wei   +7 more
doaj   +1 more source

Patient preferences of patient selection criteria for upper extremity vascularized composite allotransplantation: A qualitative study

SAGE Open Medicine, 2023
Background: Upper extremity vascularized composite allotransplantation is a life-enhancing reconstructive treatment option that aims to improve recipients’ quality of life and maximize function.
Karen B. Vanterpool, Jessica Gacki-Smith, Max C. Downey, Michelle Nordstrom, Michelle Luken, Tiffany Riggleman, Shannon Fichter, Withney Altema, Sally E. Jensen, Gregory A. Dumanian, Carisa M. Cooney, Macey L. Levan, Scott Tintle, Gerald Brandacher, Elisa J. Gordon   +14 more
doaj   +1 more source

The intragraft vascularized bone marrow induces secondary donor-specific mystacial pad allograft tolerance

Frontiers in Immunology, 2022
IntroductionVascularized bone marrow (VBM) is essential in tolerance induction through chimerism. We hypothesized that the inclusion of VBM contributes to the induction of mystacial pad allotransplantation tolerance.MethodIn this study, 19 VBM, nine ...
Cheng-Hung Lin, Madonna Rica Anggelia, Hui-Yun Cheng, Yun-Huan Hsieh, Wen-Yu Chuang, Huang-Yu Yang, Chih-Hung Lin   +6 more
doaj   +1 more source

Challenges and Opportunities in Vascularized Composite Allotransplantation of Joints: A Systematic Literature Review [PDF]

Background: Joint allotransplantation (JA) within the field of vascularized composite allotransplantation (VCA) holds great potential for functional and non-prosthetic reconstruction of severely damaged joints. However, clinical use of JA remains limited
Zhang, Lei
core   +1 more source

Cellular activation pathways and interaction networks in vascularized composite allotransplantation [PDF]

, 2023
Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive surgery that has revolutionized the treatment of patients with devastating injuries, including those with limb losses or facial disfigurement.
Mookerjee, Vikram, Knoedler, Samuel, Kern, Barbara, Murphy, George F., Kauke-Navarro, Martin, Stoegner, Viola A., Schroeter, Andreas, Sadigh, Sam, Pomahac, Bohdan, Panayi, Adriana C., Lian, Christine G., Knoedler, Leonard, Huelsboemer, Lioba, Tullius, Stefan G., Lee, Catherine A. A.   +14 more
core   +3 more sources

Targeting inflammation and immune activation to improve CTLA4-Ig-based modulation of transplant rejection

Frontiers in Immunology, 2022
For the last few decades, Calcineurin inhibitors (CNI)-based therapy has been the pillar of immunosuppression for prevention of organ transplant rejection.
Marcos Iglesias, Daniel C. Brennan, Christian P. Larsen, Giorgio Raimondi   +3 more
doaj   +1 more source

Pluripotent Stem Cells: Recent Advances and Emerging Trends

Biomedicines
The field of induced pluripotent stem cells (iPSCs) continues to evolve, offering unprecedented potential for regenerative medicine, disease modeling, and therapeutic applications [...]
Aline Yen Ling Wang, Ana Elena Aviña, Yen-Yu Liu, Huang-Kai Kao   +3 more
doaj   +1 more source

Perspectives on the use of mesenchymal stem cells in vascularized composite allotransplantation [PDF]

, 2013
Reconstructive transplantation has emerged as clinical reality over the past decade. Long-term graft acceptance has been feasible in extremity and facial vascularized composite allotransplantation (VCA) under standard immunosuppression.
Plock, Jan A, Xin Xiao eZheng, Schnider, Jonas T, Jonas T. Schnider, Zheng, Xin Xiao, Gorantla, Vijay S, Mario G. Solari, Vijay S. Gorantla, Solari, Mario G, Xin Xiao Zheng, Jan A. Plock   +10 more
core   +1 more source

Maximizing Neurovascular Outcomes of Facial Transplantation: A Comprehensive Review

Clinical Anatomy, EarlyView.
ABSTRACT Facial transplantation is a division of reconstructive surgery which aims to improve the function and appearance of a face that has endured severe disfigurement. Currently, the face transplant procedure uses allogenic tissue, harvested from a brain‐dead donor, to replace damaged facial components.
Olivia A. James, Faye Bennett
wiley   +1 more source

Mouse Models of Experimental Vascularized Composite Allotransplantation

, 2014
The clinical practice of vascularized composite allotransplantation (VCA) has been limited by the potential side effects of chronic immunosuppression. Studies using rodent models have been useful for dissecting mechanisms underlying immunological events ...
Li, Zhanzhuo, Le Moine, Alain
core   +1 more source