Results 71 to 80 of about 1,741 (203)
Vascularized composite allotransplantation (VCA) has revolutionized restorative surgery of devastating injuries. Unfortunately, these grafts undergo significant injury during prolonged cold ischemia and subsequent reperfusion.
Tessa E. Muss +15 more
doaj +1 more source
Characterization data for T cell-specific Blimp-1 transgenic C57BL/6 mice
This article is the first to provide characterization data regarding naive C57BL/6 transgenic mice with overexpression of B lymphocyte-induced maturation protein 1 (Blimp-1) under a T cell-specific pLCK promoter.
Aline Yen Ling Wang +8 more
doaj +1 more source
ABSTRACT Objectives This study aimed to investigate the functional recovery of an 8‐gene‐edited pig heart after orthotopic xenotransplantation, the characteristics of the recipient's immune responses, and the efficacy of postoperative complication management to provide comprehensive experimental evidence for the clinical translation of xenogeneic ...
Xianzhi Wang +17 more
wiley +1 more source
ABSTRACT Complement activation is a major barrier to xenotransplantation. We report detailed complement monitoring in a 58‐year‐old man who received a 10 gene–edited porcine heart expressing human complement regulators CD46 and CD55. Despite these transgenes and prophylactic systemic complement inhibition with C1 esterase inhibitor (C1INH), early ...
Michael A. Cole +25 more
wiley +1 more source
Since the start of the clinical vascularized composite allotransplantation (VCA) era over a decade ago this field has witnessed significant developments in both basic and translational research.
Duncan A Mcgrouther +3 more
core
Current status of vascularized composite tissue allotransplantation
Vascularized composite tissue allotransplantation (VCA) offers treatment options of complex functional deficiencies that cannot be repaired with conventional reconstructive methods.
Yang, Xiaoyong +3 more
core +1 more source
Canine osteoarthritis (OA) stands as a prevalent and excruciating joint condition that represents a promising application of stromal vascular fraction (SVF) treatment.
Aline Yen Ling Wang +5 more
doaj +1 more source
ABSTRACT Xenotransplantation has been iteratively improved over the last decade in pre‐clinical models, with first‐in‐human clinical trials underway. The 2025 IXA Congress in Geneva was held in parallel with meetings involving World Health Organization leaders to support the development of new guidance on xenotransplantation in this rapidly evolving ...
Corbin E. Goerlich +12 more
wiley +1 more source
Key psychosocial challenges in vascularized composite allotransplantation
Psychosocial factors are important elements in the assessment and follow-up care for vascularized composite allotransplantation (VCA) and require multidisciplinary evaluation protocols. This review will highlight differences between VCA with solid organ transplantation (SOT), provide information on the psychosocial selection of VCA candidates, ethical ...
Martin, Kumnig +1 more
openaire +2 more sources
Background: As we enter an age with new approaches to tissue reconstruction, the emphasis on the adage "like for like" has become even more relevant. This study illustrates the potential for several tailored vascularized composite allotransplantation ...
Gascoigne, Adam C. +9 more
core +1 more source

