Results 81 to 90 of about 1,741 (203)

Xenotransplantation at a Crossroads: Breakthroughs, Challenges, and the Path Forward

Organ Medicine, EarlyView.
Xiaoyu Gan, Jizhang Yu, Jie Wu, Junjie Zong   +3 more
wiley   +1 more source

Presence of Donor Lymph Nodes Within Vascularized Composite Allotransplantation Ameliorates VEGF-C-mediated Lymphangiogenesis and Delays the Onset of Acute Rejection.

, 2021
BACKGROUND The lymphatic system plays an active role in modulating inflammation in autoimmune diseases and organ rejection. In this work, we hypothesized that the transfer of donor lymph node (LN) might be used to promote lymphangiogenesis and ...
Olariu, Radu, Milusev, Anastasia, Leckenby, Jonathan Ian, Abd El Hafez, Mai Moustafa Ahmed, Lese, Ioana, Constantinescu, Mihai, Taddeo, Adriano, Tsai, Catherine, Rieben, Robert, Vögelin, Esther, Banz, Yara   +10 more
core   +1 more source

Response to Commentary on “Cryopreserved Total Skin Allografts From Living Donors for Complex Wound Management: A New Paradigm in Regenerative Wound Care”

International Wound Journal, Volume 23, Issue 7, July 2026.
Marcelo Fonseca, Aldo Cañete, Luana Mandriaza, Jennifer Gómez, Jaume Masiá, Katherine Marcelain, Dino Ibaceta, Cristian Erazo, Brenda Gámez, Monserrat Rius, Florencia Disi   +10 more
wiley   +1 more source

Xenotransplantation and Human Organ Trafficking: The Impact of Increased Organ Availability

Xenotransplantation, Volume 33, Issue 2, March/April 2026.
ABSTRACT The global shortage of organs for allotransplantation contributes to illicit trade in human organs. While clinical xenotransplantation is proposed as a potential solution to this global shortage, diverse factors contribute to human organ trafficking including global shortages, underdeveloped and under supported organ procurement ...
Daniel J. Hurst, Luz A. Padilla, Emanuele Cozzi, Jay Fishman   +3 more
wiley   +1 more source

Xenotransplantation Literature Update: July–December 2025

Xenotransplantation, Volume 33, Issue 2, March/April 2026.
ABSTRACT The second half of 2025 marked a significant transition for xenotransplantation, shifting further from experimental feasibility to early clinical translation. Prolonged physiologic support from genetically engineered porcine kidneys and livers in human recipients provided unprecedented insight into organ compatibility, rejection dynamics, and ...
Kasra Shirini, Joseph M. Ladowski, Niket Harsh, Raphael P. H. Meier   +3 more
wiley   +1 more source

The Need for Inducing Tolerance in Vascularized Composite Allotransplantation [PDF]

, 2020
Successful hand and face transplantation in the last decade has firmly established the field of vascularized composite allotransplantation (VCA).
Kadiyala V Ravindra, Suzanne T Ildstad, Hong Xu, Larry D Bozulic, David D Song   +4 more
core  

Transcriptome profiling of immune rejection mechanisms in a porcine vascularized composite allotransplantation model [PDF]

Frontiers in Immunology
Mihai Constantinescu, Robert Rieben, Radu Olariu   +2 more
exaly   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction

Current Issues in Molecular Biology
Vascularized composite allotransplantation (VCA) has emerged as a robust alternative for addressing anatomically complex defects but requires a toxic lifelong immunosuppressive regimen. Tissue engineering offers the promise of creating recipient-specific
Elise Lupon, Aylin Acun, Alec R. Andrews, Ruben Oganesyan, Hyshem H. Lancia, Laurent Lantieri, Mark A. Randolph, Curtis L. Cetrulo, Alexandre G. Lellouch, Basak E. Uygun   +9 more
doaj   +1 more source

Intra-graft injection of tacrolimus promotes survival of vascularized composite allotransplantation.

, 2017
BACKGROUND Immunosuppressive therapies derived from solid organ transplantation are effective in promoting survival of vascularized composite allotransplantation (VCA), but they cause serious side effects that are difficult to justify for this non ...
Olariu, Radu, Michael Hayoz, Banz Wälti, Yara, Franck M. Leclère, Adriano Taddeo, Mihai Constantinescu, Dzhuliya V. Dzhonova, Robert Rieben, Constantinescu, Mihai Adrian, Rieben, Robert, Thusitha Gajanayake, Gajanayake, Thusitha, Dzhonova, Dzhuliya Vihrenova, Radu Olariu, Hayoz, Michael, Denoyelle, Julie Sophie Cécile, Taddeo, Adriano, Vögelin, Esther, Esther Vögelin, Leclère, Franck-Marie Patrick, Julie Denoyelle, Yara Banz   +21 more
core   +1 more source