Longitudinal Effects of Lifetime Caffeine Consumption on Levels of Depression, Anxiety, and Stress: A Comprehensive Review. [PDF]
Unsal S, Sanlier N.
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Spinal astrocytes involved in the pathogenesis and treatment of neuropathic pain. [PDF]
Li X, Huang Y, Bai J.
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Phosphorylation state of Akt in the heart during artificial deep hypothermia in Syrian hamsters.
Horii Y+5 more
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Electroacupuncture improves cyclophosphamide-induced bladder overactivity by reducing mechanotransduction in the rat urothelium. [PDF]
Junwei HU+7 more
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Foamy macrophages in atherosclerosis: unraveling the balance between pro- and anti-inflammatory roles in disease progression. [PDF]
Ijaz A, Yarlagadda B, Orecchioni M.
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Getting to know adenosine deaminase 2 deficiency inside and out.
Ehlers L, Meyts I.
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The A1 adenosine receptor as a new player in microglia physiology
Glia, 2014The purinergic system is highly involved in the regulation of microglial physiological processes. In addition to the accepted roles for the P2X4,7 and P2Y12 receptors activated by adenosine triphosphate (ATP) and adenosine diphosphate, respectively, recent evidence suggests a role for the adenosine A2A receptor in microglial cytoskeletal rearrangements.
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The glycoprotein nature of A1 adenosine receptors [PDF]
A1 adenosine receptors from different tissues and species were photoaffinity labelled and then the carbohydrate content was examined by both enzymatic and chemical treatment. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the labelled membrane receptors shows that neuraminidase treatment alters the electrophoretic mobility of the receptor
Klotz, Karl-Norbert, Lohse, M. J.
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Allosteric modulators for the A1 adenosine receptor
Expert Opinion on Therapeutic Patents, 2004The present invention provides compounds of formula (I) wherein R1, R2, R3, R4 and Q have a meaning as defined herein in the specification. The compounds of formula (I) are allosteric modulators of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor.
BARALDI, Pier Giovanni+4 more
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The pineal organ of vertebrates produces melatonin and adenosine. In lower vertebrates, adenosine modulates melatonin production. We report herein that 2-chloro-cyclopentyl-[3H]-adenosine ([3H]CCPA: adenosine A1 receptor agonist) and [3H]-cyclopentyl-1,3-dipropylxanthine ([3H]DPCPX: adenosine A1 receptor antagonist), bind specifically to sheep pineal ...
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